艾司西酞普兰与文拉法辛治疗抑郁症对照研究

Controlled study of escitalopram and venlafaxine in treatment of depression

目的:比较艾司西酞普兰与文拉法辛治疗抑郁症的疗效与安全性。方法:采用艾司西酞普兰与文拉法辛对48例抑郁症患者进行为期6周的双盲对照研究,用汉密尔顿抑郁量表(HAMD)、临床疗效总评量表(CGI)在治疗前及治疗1、2、4、6周评定疗效;用治疗中出现的症状量表(TESS)评定不良反应。结果:治疗6周后艾司西酞普兰组与文拉法辛组的有效率分别为87.50%和83.33%,两组差异无显著性。2药起效均较快,不良反应均较轻。结论:艾司西酞普兰与文拉法辛均是安全有效的抗抑郁药。

Objective： To compare the efficacy and tolerability between escitalopram and venlafaxine in the treantment of depression. Method ： Forty-eight patients with depression were double-blindly assigned to escitalopram and venlafaxine for 6 weeks. The efficacy of all the patients were assessed with Hamilton depressive scale（HAMD） and the clinical global impression scale（CGI） before treatment and at the end of 1st,2nd,4th, 6th week treatment,and the side effects were evaluated with the treatment emergent symptom scale （TESS）. Results： After 6 weeks treatment, the effective rates of escitalopram group and venlafaxine group were 87.50% and 83.33% respectively. There was no significant difference between two groups. Both drugs took effect quickly. Conclusion： Both escitalopram and venlafaxine are effective and safe antidepressants.