良性前列腺增生的磁共振波谱与前列腺特异性抗原的相关性初步研究

Study of correlation between MRS and serum PSA in benign prostatic hyperplasia

目的:分析良性前列腺增生患者的磁共振波谱(MRS)与血清总前列腺特异性抗原(T-PSA)、游离前列腺特异性抗原(F-PSA)浓度和F-PSA/T-PSA比值的相关性。方法:30例超声引导下穿刺活检或手术切除后证实的良性前列腺增生病人,在中央区设定兴趣区后利用三维磁共振波谱(3DMRS)测定各兴趣区(胆碱+肌酸)/枸橼酸盐〔(Cho+Cre)/Cit〕的比值,计算出每位患者(Cho+Cre)/Cit比值的平均值,与其血清T-PSA、F-PSA浓度和F-PSA/T-PSA比值进行相关性分析。结果:(Cho+Cre)/Cit比值和血清T-PSA、F-PSA、F-PSA/T-PSA均无明显相关性(r分别为0.187、-0.125、-0.360,P值分别为0.323、0.510、0.051)。结论:前列腺增生症患者的(Cho+Cre)/Cit与血清T-PSA、F-PSA浓度和F-PSA/T-PSA比值无明显线性关联。

Objective： To evaluate the linear correlation between MRS and serum PSA in benign prostatic hyperplasia （BPH）. Methods： Thirty patients with benign prostatic hyperplasia verified by biopsy or postoperative pathology underwent 3D MRS examination and serum PSA assay. The average ratio of （Cho＋ Cre）/Cit was measured in each patient. Linear correlations between the ratio of （Cho-Cre）/Cit and T-PSA, F-PSA, F-PSA/T-PSA were analyzed. Results： There was no significant correlation between the ratio of （Cho＋Cre）/Cit and the T PSA, F-PSA, F-PSA/T-PSA（The value of r respectively were 0. 187, -0. 125, -0. 360, the value of P respectively were 0. 323, 0. 510, 0. 051）. Conclusion： There is not obvi ous correlation between the ratio of （Cho＋Cre）/Cit and the T PSA, F PSA, F-PSA/T-PSA in patients with benign prostate hyperplasia.