新疆和田地区维、汉两民族Apo-E基因多态性与糖尿病的关系

The correlation between genetic polymorphism of Apo-E and diabetes in uygur and Han populations

目的:研究新疆和田地区维吾尔族(维族)、汉族两民族Apo-E基因多态性与糖尿病的关系。方法:收集新疆和田地区维吾尔族、汉族正常人群与糖尿病(DM),糖尿病肾病(DN)患者载脂蛋白E(Apo-E)的遗传多态性进行分析,比较两个民族正常及患病人群载脂蛋白E(Apo-E)基因频率的遗传差异。结果:本研究在新疆维吾尔自治区和田地区维吾尔族、汉族中共发现了5种基因型,其中包括两个以C和T碱基替换为特征的多态性突变。Apo-E的基因和基因频率在维、汉族中的差异有统计学意义(P<0.01和P<0.05)。Apo-E的基因型和基因频率在正常对照组与糖尿病组之间的差异也有统计学意义(P<0.01)。结论:我们研究了同一地区维、汉两民族间Apo-E等位基因及其频率分布的差异,这种差异在不同民族的糖尿病肾病(DN)早期诊断中有一定临床意义。

Objective：Research Han and uyhur population of Apo-E genetic polymorphism with diabetic in Xinjiang hotan territory.Methods：Collect the Apo-E genetic polymorphism in normal conctrol and diabetis in Hotan territory and diabetic nephropathy patients and compare the difference befween normal and patientens in two population.Results：The study of genotype and allele of Apo-E in uygur population（n=16 in normal control,n=26 in T2DM）and Han population（n=36 in NC,n=27 in T2DM）showed that：（1）there were five genotypes detected;（2）there were differences in Apo-E genotypes and gene frequency between uygur and Han populations and between groups of T2DM and normal control（all P〈0.05）.Conclusions：We investigated the Apo-E genetype and gene frequency distribution in same area Uyhur and han population this difference had an clinical significance in early diagnosis of different population diabetic nephropatly patient.