川芎嗪对犬血管成形术局部血栓形成的影响

Effects of Ligustrazine on the Thrombosis of PTRA Site in Canine Renal Artery Stenosis Model

了解川芎嗪对预防 PTA 后血栓形成的影响。选用10条实验性肾动脉狭窄犬,随机分为对照组和实验组,每组5条。实验组 PTRA 前15日开始静滴川芎嗪注射液,40mg/kg。实验组于给药前、PTRA 前及术后4小时,对照组于 PTRA 前和术后4小时分别采集外周静脉血,作血小板聚集、TXB_2和6-酮-PGF_测定。PTRA后4小时将犬处死,处死前切取成形侧肾动脉,测量 PTRA 局部血栓体积。结果显示:川芎嗪可显著抑制血小板聚集和血小板 TXA_2的产生,明显增加血管内皮合成释放 PGI_2,显著阻止 PTRA 局部血栓的形成。表明川芎嗪是一种有效预防 PTA 后血栓闭塞性再狭窄的药物。

Purpose:To understand the effect of ligustrazine on preventing the thrombosis 'after percutaneous transluminal angioplasty(PTA).Materials and Methods:Dogs models(n=10)with exper- imental renal arterial stenosis were selected and randomly divided into control and experimental groups with 5 dogs for each. Experimental group dogs were injected ligustrazine(40mg/kg)15 days before PTRA.Peripheral blood samples were collected before recelived drug,before and 4 hours after PTRA in the experiment group;before and 4 hours after PTRA in the control group.Plasma concentrations of thromboxane B2_(TXB_2)and 6-keto-PGIlα were determined by radioimmunoassay.Rates of platelet ag- gregation were also determined by ADP-induced.All dogs were killed 4 hours after PTRA.Renal arteries were removed before killing.The thrombus volume at PTRA sites were measured.Results:Liguslrazine might significantly inhibit platelet aggregation,decrease TXA_2 produced by platelet and increase PGI_2 synthesized in the blood vessel.Therefore,ligustrazine might significantly inhibit thrombosis at the PTRA sites.It Suggests that Ligustrazine could be an effective drug for preventing restenosis of thromboses after PTA.