肝动脉化疗栓塞治疗转移性肝癌25例分析

An Analysis of Therapeutic Results of Hepatic Arterial Chemo-Embolization in 25 Cases with Metastatic Hepatic Cancer

目的:通过肝动脉化疗栓塞治疗转移性肝癌的疗效分析,提出影响疗效的有关因素。材料与方法:转移性肝癌25例(其中24例肝多发性转移,23例少血管型)。瘤体直径1.2～5.5cm,平均3.2cm。经肝因有动脉注入5-Fu750～1000mg,CDDP60～80mg,碘油乳剂(40％碘化油6～10ml加MMC16～20rag),0.2～0.5cm明胶海2～3条栓塞治疗。结果:按照WHO实体肿瘤近期疗效标准,CR1例、PR5例、NC15例、PD4例,有效率24％(CR+PR)。中位生存11.3月。结论:肝动脉化疗栓塞治疗转移性肝癌是一种有效的方法。

Objective: By analysing the curative effects of hepatic arterial chemo- embolization in metastatic hepatic cancer and summarizing the relevant factors that influenced the decreasing rate of the tumor, we may improve the curative effects in the future. Methods: 25 cases of metastatic hepatic cancer were treated by trans- proper hepatic arterial infusion with 5-Fu 750～1000mg. CDDP 60～80mg, Lipiodol emulsion (40% Lipiodol 6-10ml adds MMC 16～20mg) and 1～3 pieces of gelfoam in length 0.2～0.5cm. Among the 25 cases, 24 were multiple metastasis, 23 were less vascular type of tumor blood supply, and the diameter of the tumor it self varied from 1.2～5.5cm, averaged 3.2em. Results: CR1 case; PR 5 cases; NC 15 cases; PD 4 cases. The effect rate is 24%. The middle existing time is I1.3 months. Conclusion: Treatment for hepatic cancer (including primary and metastatic) with chemo- embolization of hepatic: artery is an effective method but the decrease in tumor size in the metastatic hepatic cancer is poorer than that in the primary hepatic cancer.