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RIP140在女性生殖和脂代谢中的作用 被引量：1

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摘要 细胞核感受体通常是在精确的时间周期内,通过控制具体的细胞目标基因,调控着大量内分泌反应。它们调节基因复制的能力主要是依靠共活化剂及共抑制剂来完成的,在为数众多的关于共激化剂报道中,160蛋白家族类固醇受体辅激活因子（steroid receptor coactivator，P160／SRC）在许多细胞核感受器成员的复录活化中发挥着重要的作用。
作者 张锁 侯丽辉 吴效科
机构地区 黑龙江中医药大学附属第一医院
出处 《世界中西医结合杂志》 2008年第3期183-184,共2页 World Journal of Integrated Traditional and Western Medicine
关键词 RIP140 细胞核抑制质 排卵 子宫功能 脂代谢
分类号 R711.7 [医药卫生—妇产科学]
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参考文献9

  • 1[1]Mckenna NJ,O'Malley BW.Combinatorial control of gene expression by nuclear receptors and coregulators[J].Cell,2002,108(4):465-474.
  • 2[2]Nagy L,Kao HY,Chakravarti D,et al.Nuclear receptor repression mediated by a complex containing SMRT,mSin3A,and histone deacetylase[J].Cell,1997,89(3):373-380.
  • 3[3]Jepsen K,Hermanson O,Onami TM,et al.Combinatorial roles of the nuclear receptor corepressor in transcription and development[J].Cell,2002,102(6):753-763.
  • 4[4]White R,Leonardsson G,Rosewell I,et al.The nuclear receptor corepressor nrip1 (RIP140)is essential for female fertility[J].Nat Meal,2000,6(12):1 368-1 374.
  • 5[5]Leonardsson G,Jacobs MA,White R,et al.Embryo transfer experiments and ovarian transplantation identify the ovary as the only site in which nuclear receptor interacting protein 1/RIP140 action is crucial for female fertility[J].Endocrinology,2002,143 (2):700-707.
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同被引文献16

  • 1Cavailles V, Dauvois S, L'Horset F, et al. Nuclear factor RIP140 modulates transcription activation by the estrogen receptor[J]. EMBO J, 1995, 14(15): 3741-3751.
  • 2White R, Leonardsson C Rosewell I, et al. The nuclear receptor co-repressor nripl (RIP140) is essential for fe- male fertility [J]. Nat Med, 2000, 6(12): 1368-1374.
  • 3Christian M, Kiskinis E, Debevec D, et al. RIP140-tar- t1 geted repression of gene expression in adipocytes[J]. Mol / Cell Biol, 2005, 25(21): 9383-9391.
  • 4Seth A, Steel J H, Nichol D, et al. The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle [J]. Cell Metab, 2007, 6(3): 236-245.
  • 5Herzog B, Hallberg M, Seth A, et al. The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor [J]. Mol Endocrinol, 2007, 21(11): 2687- 2697.
  • 6Zschiedrich I, Hardeland U, Krones-Herzig A. Coactivator function of RIP140 for NFKB/RelA-dependent cytokine gene expression [J]. Blood, 2008, 112(2): 264-276.
  • 7Leonardsson G, Jacobs M A, White R. Embryo transfer experiments and ovarian transplantation identify the ovary as the only site in which nuclear receptor interacting pro- tein 1~RIP140 action is crucial for female fertility [J]. En- docrinology, 2002, 143(2): 700-707.
  • 8Malan S Wl The improved Boer goat[J]. Small Ruminant Research, 2000, 36(2): 165-170.'.
  • 9Christian M, White R, Parker M G. Metabolic regulation by the nuclear receptor corepressor RIP140[J]. Trends Endocrinol Metab, 2006, 17(6): 243-250.
  • 10White R, Morganstein D, Christian M, et al. Role of RIP140 in metabolic tissues: connections to disease[J]. FEBS Lett, 2007, 582(1): 39-45.

引证文献1

世界中西医结合杂志
2008年 第3期

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