宫颈上皮内瘤样病变子宫颈环形电切术后临床效果评价

Clinical Evaluation of LEEP for Cervical Intraepithelial Neoplasia

目的:探讨子宫颈环形电切术治疗宫颈上皮内瘤样变(CIN)的临床疗效。方法:将84例CIN患者随机分为冷刀子宫颈锥切术(CKC)组41例与子宫颈环形电切术(LEEP)组43例,两组分别施CKC与LEEP术式治疗,对比研究两种术式治疗CIN的疗效、各术式优点及并发症情况。结果:CKC组平均手术时间为29min,术中平均出血量45mL;LEEP组平均手术时间为7min,术中平均出血量10ml,两组间比较具有显著性差异(P<0.01)。CKC组患者术后半年随访复发7例(CINⅡ级3例,CINⅢ级4例),治愈34例,治愈率82.93%,LEEP组患者术后半年随访复发5例,治愈38例,治愈率88.37%;CKC组术后半年复查高危型HPV感染率为31.7%,LEEP组为32.56%。两组间治愈率、HPV感染率比较有显著性差异(P<0.05)。结论:子宫颈环形电切术在治疗CIN中具有重要价值,是治疗CIN较理想的方法。

Objective：To investigate the clinical significance of loop electrosurgical excison procedure（LEEP）of cervix for cervical intraepithelial neoplasia （CIN）. Methods：84 cases of CIN were divided into CKC group by 41 cases and LEEP group by 43 cases randomly. The curative effect, complication and merits of each operation for CIN were compared. Results： The average operation time was 29 min, and the average hemorrhage volume was 45 mL in CKC group. While the time was 7 rain and volume was10 mL in LEEP group. The result showed significant difference（P〈0.01）. 7 cases relapsed half year after the operation in CKC group（3 CIN Ⅱ ,4 CINⅢ ）. 34 cases were cured and curative rate was 82.93%. 5 cas- es relapsed half year after the operation in LEEP group. 38 cases were cured and curative rate was 88.37%. The high risk rate of HPV infection was 31.7% in CKC group,while it was 32.56% in LEEP group half year after the operation. The curative rate and HPV infection were different significantly between groups（P〈0.05）. Conclusion：LEEP of cervix has important value for cervical intraepithelial neoplasia, and is the ideal treatment for CIN.