FDP对冠心病合并心力衰竭老年患者的疗效

Effects of FDP on coronary heart disease with cardiac failure in senile patients

目的研究1,6-二磷酸果糖(fructose-1,6-diphosphate,FDP)治疗冠心病合并心力衰竭的疗效。方法92例冠心病合并心力衰竭老年患者随机分为对照组、治疗组,对照组静脉滴注硝酸酯类等药物,治疗组加用FDP 14 d,观察治疗前后两组患者临床症状及心排血量(cardiac output,CO)、心脏排血指数(cardiac index,CI)、射血分数(ejection fraction,EF)等心脏功能指标变化。结果经2周治疗后,治疗组和对照组的总有效率分别为72.92%、52.27%,治疗组优于对照组(P<0.05);对照组干预前CO、CI、EF分别(3.80±0.92)L/min、(2.21±0.46)L/(min.m-2)、(40±12)%,干预后分别增加至(4.32±0.81)L/min、(2.42±0.45)L/(min.m-2)、(45±9)%,治疗前后各指标差异均有统计学意义(P均<0.05);治疗组干预前CO、CI、EF分别(3.71±0.87)L/min、(2.14±0.42)L/(min.m-2)、(38±13)%,干预后分别增加至(5.04±0.68)L/min、(3.01±0.34)L/(min.m-2)、(53±12)%,治疗前后各指标差异均有统计学意义(P均<0.05),治疗组与对照组治疗后比较差异亦有统计学意义(均P<0.01)。结论FDP对冠心病心力衰竭老年患者具有良好的治疗效果。

Objective To study the effects of fructose-1, 6-diphosphate （FDP） on coronary heart disease with cardiac failure in senile patients. Methods Ninety-two senile patients with coronary heart disease and cardiac insufficiency were randomly divided into treatment group and control group. A routine comprehensive therapy was given to all patients to improve cardiac function and FDP was additionally administered to the patients in treatment group for fourteen days. The clinical symptoms, cardiac output （CO）, cardiac index （CI） and ejection fraction （EF） of the patients before and after treatment were analyzed. Results At the end of management, total effective rate of treatment group was higher than that of control group （72.92%, 52.27% respectively, P 〈 0.05 ）. The average CO, CI and EF before the management in control group were （3.80 ±0.92） L/min, （2.21± 0.46） L/min/m^2 and （40 ± 12）% respectively and increased to（4.32 ± 0.81 ） L/min, （2.42 ± 0.45 ） L/min/m^2 and （45 ± 9 ） % respectively after the management （ all P 〈 0.05 ）. The average CO, CI and EF before the management in treatment group were（3.71±0.87）L/min, （2.14 ± 0.42） L/min/m^2 and （ 38 ± 13 ） % respectively and increased to （ 5.04 ± 0.68 ） L/min, （ 3.01 ± 0.34 ） L/ min/m^2, （53 ± 12）% respectively after the management （all P 〈0.05 ） while the improvement of CO, CI and EF in treatment group dramatically surpassed that in control group （ all P 〈 0.01 ）. Conclusion FDP is helpful to relieve the symptoms and improve the cardiac function in senile patients with coronary heart disease and heart failure.