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晚期糖基化终末产物对小鼠骨髓干细胞向血管内皮细胞分化的影响 被引量：2

Effects of advanced glycation end-products on differentiation of vascular endothelial cells from bone marrow stem cells of mice
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摘要 观察晚期糖基化终末产物（AGEs）对骨髓干细胞（BMSC）向内皮细胞分化的影响。结果发现，20μg／ml AGEs对BMSC分化的影响不明显，100μg/ml AGEs使BMSC分化能力明显下降，血管内皮生长因子受体2阳性细胞计数和百分数均明显降低。 The effects of advanced glycation end-products （AGEs） on number and activity of vascular endothelial cells （ VEC ） from bone marrow stem cells （ BMSC ） of mice were investigated. 100 μg/ml AGEs markedly inhibited differentiation of BMSC into VEC with decreased vascular endothelial growth factor receptor-2 positive cells, but 20 μg/ml AGEs had no effect.
作者 许淑芳 李裕明 陈璐璐
机构地区 华中科技大学同济医学院附属协和医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2008年第5期548-549,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 糖基化终产物 高级 骨髓于细胞 内皮细胞 分化 Glycation end-products, advanced Bone marrow stem cells Vascular endothelial cells Differentiation
分类号 R587.2 [医药卫生—内分泌]
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参考文献9

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  • 2Tateishi-Yuyama E, Matsubara H, Murohara T, et al. Therapeutic angiogenesis for patients with limb ischemia by transplantation of autologous bone marrow cells: a pilot study and a randomized control trial. Lancet, 2002,360:427-435.
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  • 8汤玮,刘志民.糖尿病微血管病相关蛋白的研究进展[J].中华内分泌代谢杂志,2007,23(2):189-192. 被引量：11
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二级参考文献51

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中华内分泌代谢杂志
2008年 第5期

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