摘要
DNA疫苗具有较大的临床应用前景，但其免疫效力还不够强大，尤其在大动物和人类中。CTLA-4融合基因免疫能同时增强机体的特异性体液和细胞免疫应答，在抗感染、抗肿瘤中显示巨大的应用前景，并且其免疫增强效应已在部分大动物体内得到证实。
DNA vaccine has shown great prospects in clinical application, but its immune potency is limited, especially in large animals and mankind. Vaccination with the fusion gene encoding the extracellular domain of CTLA-4 fused to the specific antigen is ＇able to enhance both humoral and cellular immtme reponses in several kinds of large animals, which represent a promising approach in the treatment of infectious diseases and cancers.
出处
《国际流行病学传染病学杂志》
CAS
2008年第5期319-322,共4页
International Journal of Epidemiology and Infectious Disease
基金
国家科学自然基金（30471537）
