摘要
HIV的典型遗传特征之一是高度的遗传多样性，这一特征为艾滋病患者的抗病毒治疗和HIV疫苗的研制带来了困难，然而也为研究人群中病毒的传播和进化提供了有利条件。根据HIV基因序列和氨基酸序列的特征，HIV-1可分为多种亚型。对HIV-1基因亚型的分析，可敏感地提示HIV的流行信息，及早发现新的HW亚型毒株的传播，预测HIV流行趋势，为艾滋病诊断试剂的更新换代、HIV疫苗的研制提供依据，还可用于估计疾病进展及抗病毒药物治疗的敏感性与耐药性，在预防和控制艾滋病方面发挥重要作用。
One of the typical genetic characteristics of HIV is its high genetic diversity, which brings difficulties to antiretrviral therapy for the AIDS patients and the development of HIV-1 vaccine. However, it also provides favorable conditions for studying the spread and evolution of the virus. HIV-1 is divided into a variety of subtypes according to the gene sequence and amino acid sequence. Based on the analysis of HIV-1 gene subtype, firstly, the HIV epidemic information will be shown sensitively and the successor of a new HIV-I subtype can be early detected, and the epidemic trends of HIV can be forecast; secondly, meaningful data can be provided for the replacement of diagnostic reagents and the development of HIV-I vaccine; thirdly, disease progression of AIDS and sensitivity and resistance of antiretroviral therapy can be estimated. After all, HW-1 subtype plays an important role in the prevention and control of AIDS.
出处
《国际流行病学传染病学杂志》
CAS
2008年第5期323-326,共4页
International Journal of Epidemiology and Infectious Disease
基金
广州市重大科技攻关项目（200621,E0091）
广州市医药卫生科技重点项目（2005-Zdi-04）
