摘要
高迁移率族蛋白B-1（HMGB1）是一种重要的晚期炎症介质，可以由坏死细胞被动释放，也可以由被激活的巨噬细胞或单核细胞主动分泌到细胞外介导炎症反应。急性肝衰竭时，内毒素血症发生率极高，HMGB1可能参与了急性肝衰竭的病理生理过程并发挥了重要作用。HMGB1将在临床上为抗急性肝衰竭提供新的治疗靶点。
High mobility group box 1 protein （HMGB1） is an important potential late mediator. It can be both passively released by necrotic cells and actively secreted by macrophages or monocytes stimulated with proinllammatory cytokines. The secretion of HMGB1 mediates inflammatory reaction. The incidence of endotoxaemia is very high in acute liver failure, HMGB1 possibly attends the pathophysiological process of acute liver failure and plays an important role.HMGB1 will expand the SCOld： for the clinical treatment of acute liver failure patients.
出处
《国际流行病学传染病学杂志》
CAS
2008年第5期336-339,共4页
International Journal of Epidemiology and Infectious Disease
