摘要
目的:在纯钛表面构建纳米TiO2涂层并探索最佳的工艺条件。方法:采用溶胶凝胶法在纯钛表面构建纳米级TiO2涂层,用X线衍射和扫描电镜表征其晶体结构、表面形貌以及厚度,筛选出最佳的热处理温度和涂层厚度;用体外成骨细胞培养评价其生物活性。结果:热处理温度为500℃的单层TiO2涂层具有良好的晶体结构和均匀的纳米级表面形貌,与钛基底结合牢固。体外成骨细胞培养显示其具有良好的生物活性。结论:本实验构建的TiO2涂层具有良好的性能,为后续复合性梯度功能涂层的设计和组装打下了基础。
Objective： This research was aimed at the construction and characterization of nano-TiO2 bioceramic coating on titanium surface. Methods： Nano-TiO2 coating was constructed on the surface of commercially pure titanium by sol-gel route. X-ray diffraction （XRD） and scanning electromicroscope （SEM） were employed to characterize the obtained coating, and the best technical conditions were determined. In vitro cellular responses of osteoblasts to the coating were evaluated by MTT assay, ALP assay and SEM observation. Results： The nano-TiO2 biocoating has good crystallization and homogeneous, nano-scale surface morphology. The best technical conditions are 500℃ heat-treatment and sin- gle layer coating. The in vitro osteoblasts culture exhibits satisfactory bioactivity. Conclusion： The nano-TiO2 biocoating on titanium surface has sound properties for the future assembly of functionally gradient composite biocoating.
出处
《中国口腔种植学杂志》
2008年第3期101-104,135,共5页
Chinese Journal of Oral Implantology
基金
高等学校博士学科点专项科研基金资助
资助号:20020610063
