摘要
目的:研究藿胆丸治疗鼻炎-鼻窦炎的细胞免疫作用,探讨藿胆丸的作用机理,为临床应用提供科学依据。方法:采用细胞免疫学研究藿胆丸不同时相含药血浆对小鼠外周血白细胞、腹腔巨噬细胞和脾淋巴细胞的影响。结果:21.6g/kg藿胆丸3.0h和4.0h含药血浆对小鼠外周血白细胞均具有显著的活化作用(P<0.01,P<0.05);4.0h含药血浆对小鼠脾淋巴细胞具有非常显著的活化作用(P<0.01);各时相含药血浆对小鼠腹腔巨噬细胞均无明显活化作用(P>0.05)。结论:藿胆丸通过活化外周血白细胞和脾淋巴细胞而增强机体免疫功能是其治疗鼻炎-鼻窦炎的机理之一。
Objective：Therapeutic mechanism of Huodan pill was studied to provide scientific basis for clinic. Methods： Serum pharmacology was used to studied immunity effect of different time drug-containing serum of Huodan pill on leukocytes, abdominal cavity macrophage and spleen lymphocytes. Results：3.0 h and 4.0 h drug-containing serum of 21.6g/kg Huodan pill has obviously activation effects on leukocytes （P〈0.01 ,P〈0.05）. 4.0 h drug-containing serum has very obviously activation effects on spleen lymphocytes （P〈0.01）,but all of drug-containing serum has no obviously activation effects on abdominal cavity macrophage（P〉0.05）. Conclusion：Huodan pill treating mechanism for rhinitis-nasosinusitis was due to the activation effects on leukocytes and spleen lymphocytes.
出处
《世界中西医结合杂志》
2008年第6期330-332,共3页
World Journal of Integrated Traditional and Western Medicine
