特异性免疫疗法治疗慢性荨麻疹疗效研究

Effect study of SIT to allergic urticaria

目的:通过对照的方法比较特异性免疫疗法治疗慢性荨麻疹的疗效。方法:将68例慢性荨麻疹患者随机分为2组,治疗组34例,对照组34例。分别给予包括脱敏治疗在内的综合治疗及传统的药物治疗。结果:治疗组患者的总有效率为88.2%,对照组总有效率为82.4%,2组疗效没有明显差别(P>0.05)。治疗组复发率为11.8%,治愈率为76.5%,而对照组为复发率为50.0%,治愈率为32.4%。2组之间分别配对检验具有显著的统计学差异(P<0.01)。结论:特异性免疫疗法在慢性荨麻疹的治疗中效果明显,尤其是远期疗效,可明显减少症状复发以及抗组胺药物的用量。

OBJECTIVE To analye efficacyecty of specific immunotherapy （SIT） to chronic urticaria by comparison. METHODS 68 cases of chronic urticaria were divided into 2 group,the therapeutic group （34 cases,given the SIT ＆ drug therapy） and the control group （34cases,given drug therapy）. RESULTS The effective rate of therapeutic group was 88. 2%,and the effective rate of control group was 82. 4%, there was no significant difference between them （P〉0. 05）. But, the relapse ＆ the cure rates of therapeutic group were 11.8% and 76. 5%. the rates of control group were 50. 0% ＆ 32. 4%, there were significant difference between them（P〈0. 01）. CONCLUSION SIT has a significant effect to chronic urticaria, especially the longterm cure effect, it can decrease the relapse of chronic urticaria.