肠易激综合征动物模型研制现状和进展

Current research situation and progress in building animal model of irritable bowel syndrome

肠易激综合征(IBS)是一种常见的肠功能紊乱性疾病,特点是慢性反复发作的腹痛、腹部不适及排便习惯的改变。发病机制目前尚未阐明。研究显示IBS可能与肠道动力、内脏感觉过敏和肠道感染等因素有关。此文对IBS动物模型研制现状及展望作一综述。

Irritable bowel syndrome（IBS） is a common disease of intestinal disorder. It is characterized by chronic or recurrent abdominal pain or discomfort along with altered bowel function. The underlying mechanisms of IBS remain unclear. Several studies showed that the attack of IBS might be related to the gastrointestinal motility, visceral hypersensitivity, infection of the bowel and several other factors. This article reviews the current research of IBS animal model.