幽门螺杆菌感染与食管鳞癌关系的研究

A research of the relationship between the infection of helicobacter pylori and esophageal squamous cell carcinoma

目的研究Hp感染与食管鳞癌的相关性。方法对试验组96例(上海同济医院2003至2007年间由病理明确为食管鳞癌)患者及对照组157例(同时期体检中心、门诊行胃镜检查,并取活检,病理无明显异常或仅有慢性浅表性胃炎)入选者分别行Hp快速尿速酶试验检查、计算两组Hp感染率并进行卡方检验统计比较;对食管癌患者按照年龄、性别、肿瘤大小、分段、有无淋巴结转移分组,分别计算Hp感染率并进行卡方检验统计比较。结果食管鳞癌患者Hp的感染率高于对照组Hp的感染率(P<0.05),有明显的统计学意义;Hp的感染与食管癌淋巴结是否转移有关(P<0.05),有明显的统计学意义;与食管癌患者的年龄、性别、肿瘤大小、分段无关(P>0.05),结论Hp的感染与食管鳞癌及食管鳞癌的淋巴结转移呈正相关,对食管癌的防治有一定的指导意义。

Objective To investigate the reIationship between the infection of Hp and esophageal squamous cell carcinoma （ESCC）. Methods 96 cases of trial group are confirmed by pathology as esophageal cancer in Shanghai Tongji hospital from 2003 to 2007, the other 157 cases of the control group who are selected from medical eentres, outatient clinic in the same period, are confirmed by pathology, as only chronic superficial gastritis or basic normal, all of them took a rapid urine test. Hp infection rates were calculated in both two groups then use card statistics to compare. According to age, gender, tumor size, lymph node＇s metastasis and partition, we divided the patients in the trial group into five parts. Hp infection rates were calculated in these parts then use card statistics to compare. Results The infection rate of Hp of ESCC is higher than that of the tri al group （P〈0.05）. Although the infection rate of Hp of the ESCC patients who have been proved of the lymph node metastasis is much higher than that of the patients who have been proved no lymph node metastasis（P〈0.05） ,there is no significant different between the infection rate of Hp and age, gender, tumor size and partition（P〉0.05）. Conclusion Our finding suggest that Hp infection and ESCC was positively correlated, and the relationship between Hp infection and the ESCC patients who have been proved of the lymph node metastasis is the same. It also have a certain significance for the prevention and treatment of esophageal cancer.