妊娠期高血压疾病患者心肌损伤的临床研究

Clinical investigation of myocardial impairment in patients with preeclampsia

目的观察子痫前期患者是否伴有心肌损伤以及心肌损伤与血脂和血压的关系。方法28例子痫前期患者,选取28例正常孕妇作对照组,观察入院时血压,同时检测血清肌钙蛋白I成分含量、总胆固醇和低密度脂蛋白含量。分析心肌损伤与血压和血脂的关系。结果子痫前期患者35.71%伴有心肌损伤。子痫前期患者血清总胆固醇和低密度脂蛋白含量高于正常孕妇,但与心肌损伤无明显关系。心肌损伤与血压水平有关。血压高于180/110mmHg的患者多伴有心肌损伤。结论对子痫前期患者应该加强心脏损伤方面检测,血压过高的患者更应该注意检测并及时处理。

Objective To investigate the main risk factors and mechanism of myocardial impairment in patients suffered from preeclampsia. Methods Blood pressure was measured and cTnI, cholesterol and LDL in serum were detected in 28 patients with preeclampsia, with 28 healthy pregnant women as control. Results It was found that 35.7% patients suffered from preeclampsia had myocardial impairment. Concentrations of cholesterol and LDL in serum were significantly higher in patients with preeclampsia than those in healthy pregnant women, and there was no relationship between concentrations of both and myocardial impairment in patients with preeclampsia. Myocardial impairment was related with blood pressure. The investigation found most of the patients with blood pressure higher than 180/110mmHg had myocardial impairment. Conclusion Myocardial impairment is apt to occurred in patients with preeclampsia, especially in those with blood pressure higher than 180/110mmHg. Early and effectively treatment of high blood pressure in patients with preeclampsia may play a role in preventing myocardial impairment.