步长脑心通治疗血管性痴呆的临床分析

Clinical analysis on Buchang Naoxintong in treating patients with vascular dementia

目的观察步长脑心通治疗血管性痴呆的临床疗效。方法选取60例血管性痴呆患者,分为对照组和脑心通治疗组,分别于服药前、服药后1、6个月观察评分。治疗组加服步长脑心通胶囊(1.6g,每日3次),1个月为1个疗程,连用6个疗程。采用简易智力状态量表(MMSE)及日常生活能力量表(ADL)评价患者智力及日常生活能力。同时检测患者血浆黏度、红细胞压积、纤维蛋白原等血液流变学指标。结果治疗组较对照组MMSE及ADL评分改善明显,血液流变学指标降低明显,差异有统计学意义(P<0.05);治疗1个月和6个月后各指标与治疗前比较差异有统计学意义(P<0.05)。结论步长脑心通治疗血管性痴呆有一定的疗效,值得临床推广应用。

Objective To observe the clinical effect of Buchang Naoxintong in treating patients with vascular dementia. Methods Sixty patients with vascular dementia were randomly divided into control group and Naoxintong group treated with Buchang Naoxintong capsule （1.6, rid, for 6 months）. Mini-mental state examination （MMSE） scores and Activity of Daily Living Scale （ADL） scores of 2 groups were assessed and hemorheological changes （plasma viscosity, hematocrit, fibrinogen, and so on） were observed and compared statistically before treatment and 1 month, 6 months after treatment. Results MMSE scores and ADL scores were improved and hemodynamics was markedly improved in Naoxintong group compared to thase of control group. There were significant differences between the 2 groups （P〈0.05）. There was also significant difference in pre-treatment subgroup,post- 1-month subgroup and post-6-month subgroup in Naoxintong group （P〈0.05）. Conclusion The Buchang Naoxintong has a better clinical effect in treating patients with vascular dementia.