摘要
本文对藻蓝蛋白复合物保护化学性肝损伤的功效学进行了研究。以Wistar大鼠建立酒精性肝损伤模型,将藻蓝蛋白复合物分为高、中、低三个剂量组,以联苯双酯作为阳性对照组,灌胃给药42d,分别测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清丙二醛(MDA)、谷胱甘肽(GSH)、肝匀浆丙二醛(MDA)和谷胱甘肽(GSH)的含量,并对肝脏切片进行病理检查。结果表明:藻蓝蛋白复合物对血清ALT、AST具有显著的抑制作用,显著拮抗肝脏MDA的升高,显著提高肝脏GSH-Px含量。出现肝细胞浊肿、脂肪变性、点状坏死的大鼠数目极少。从而表明藻蓝蛋白复合物具有显著的保护酒精性肝损伤的功效。
The protective effect of phyeocyanin compound on alcohol-induced liver injury in mice was studied. The mice were randomly divided into three groups according to their weight, the normal control group, diphenyl bibenzoate groups; phycoeyanin groups. After feeding with phycocyanin compound for 42 d, the contents of ALT, AST in serum and the content of MDA, GSH-Px in liver were measured. The results showed that the phyeocyanin compound could obviously control the contents of ALT,AST in serum,prevent the rise of MDA in liver and enhance the content of GSH-Px in liver. The pathological changes such as cell swell, grease denature, spot necrosis were few. The results indicated that phycocyanin compound has significant protective effect on the mouse liver injury induced by alcohol.
出处
《天然产物研究与开发》
CAS
CSCD
2008年第5期907-910,共4页
Natural Product Research and Development
基金
中国科学院“西部之光”人才培养计划项目
关键词
藻蓝蛋白
酒精性肝损伤
保护作用
hycocyanin compound
liver injury induced by alcohol
protective effect
