锌原卟啉对白血病早期诊断的临床意义

Clinical significance of zinc protoporphyrin in early diagnose of leukemia

目的探讨锌原卟啉（ZPP）对白血病早期诊断的价值。方法采用国产ZPP-3800型血液锌原卟啉测定仪，分析1109例血液疾病病人及50例正常对照者的ZPP含量。结果发现缺铁性贫血ZPP值最高，MDS、白血病次之，再障（AA）、其它贫血次之，均高于正常对照组，而恶性肿瘤最低，低于正常对照组及其它疾病组（P〈0．01）；白血病各类型间，虽然有着不同程度的差异，但经统计学处理，相互间无显著性差异，P〉0．05；白血病病程中，随着疾病的进展ZPP呈线性关系；良性肿瘤及其它良性疾病与正常对照结果相似，P〉0．05。结论ZPP测定，对白血病早期诊断有重要实用价值，并对辅助治疗监测及判断白血病进展有重要意义。

Objective To discuss the value and clinical significance of zinc protoporphyrin（ZPP） in early diagnose of leukemia. Methods The blood ZPP content in 1109 patients, including leukemia patients and 50 normal people were analyzed with the homemade ZPP-3800 type determined apparatus. Results ZPP content in iron deficiency anemia was the most, and the next in order was myelodysplastic syndrome, leukemia, aplastic anemia and other anemia. They all were higher than normal group （P〈0.01）.Malignant tumor was the lowest, and it was lower than other illness group and normal group （P〈0.01）. Benign tumor and other benign illness ZPP content were similar to normal group, and there was no significant difference in the three group （P〉0.05）. With the development of leukemia, ZPP content showed linear relation. In various types of leukemia, ZPP content was no significant difference（P〉0.05）. Conclusions Detection of ZPP content might have an important practical value and clinical significance in monitoring the treatment and progress of leukemia.