摘要
CD40是分子量为45—50KD的Ⅰ型跨膜糖蛋白,属于肿瘤坏死因子受体(TNFR)超家族成员,表达于多种抗原递呈细胞、内皮细胞、上皮细胞、造血前体细胞、成纤维细胞以及某些肿瘤细胞。通过单克隆抗体激发CD40分子不仅可以直接作用于CD40^+分子的肿瘤细胞,其介导的信号还可在多个环节影响肿瘤发生、发展,如调控细胞增殖/凋亡,增强其它治疗手段的敏感性,并能通过调节适应性和固有免疫应答而起到抗肿瘤作用,广泛应用于肿瘤治疗。
CD40, a member of tumor necrosis transmembrane glycoprotein, and is identified factor receptor (TNFR) superfamily, is a 45-50KD type I in many cell types including B lymphocytes, dendritic cells macrophages, endothelial cells, epithelial cells, haematopoietic progenitors, fibroblasts and many carcinoma cells. Activating CD40 through monoclonal antibodies not only directly affects CD40^+ tumor cells, but also influences tumorigenesis, progression via many mechanisms, such as inducing cell apoptosis, promoting sensitivity to other treatment and regulating immune response.
出处
《世界肿瘤杂志》
2008年第3期222-224,共3页
Tumour Journal of the World
基金
国家自然科学基金项目(30571690)