蛋白脂质微粒体Saposin C-dops能增强小鼠免疫功能

Proteolipids microsomal Saposin C-dops can enhance immune function in mice

目的:研究新型抗肿瘤药Saposin C-dops对小鼠免疫功能的影响。方法:采用实效药量及其10倍药量的Saposin C-dops给雌性B6小鼠进行连续7d腹腔注射给药后,检测小鼠脾脏中与肿瘤免疫相关的免疫细胞、血清中的细胞因子和IgG含量的变化,从而判断其在正常药量和超量情况下对健康小鼠免疫力的影响。结果:Saposin C-dops在正常用药量情况下对小鼠免疫功能有显著激活效应,这种激活效应不是剂量依赖的,而且在超量应用的情况下对小鼠免疫功能不产生负面影响。结论:Sapo-sin C-dops具有免疫激活剂的作用,能增强小鼠的免疫功能。

Objective To investigate the effect of the new-type antineoplastic agents Saposin C-dops on the immune function of mice. Methods Twenty-four female B6 mice were intraperitoneally injected with a regular and 10 times of the medication. We detected immune cells relating with oncologic immune in the spleen and immune factors in the serum, and determine its impact on the mouse immune system. Results Saposin C-dops activated the immune function of mice in a dose-independent manner, even over-dose did not have a negative impact on mice immune function. Conclusion Saposin C-dops,an immune activator,enhances the immunity of mice.