含黄素单氧化酶3(FMO3)结构、功能及其基因多态性的研究进展

Advance in flavin-containing monooxygenase 3(FMO3):structure/function and genetic polymorphisms

含黄素单氧化酶3(flavin-containing monooxygenase 3,FMO3)是一种重要的肝微粒体酶,参与体内大量药物、外源性物质和其他一些化学物质的氧化代谢。FMO3基因存在多态性,其中的一些基因突变可以引起酶活性改变,从而改变底物的代谢。体内外许多研究证明FMO3有明显的个体差异和种族差异,因此,FMO3的遗传变异在药物研制和个体化治疗中将起着重要的作用。该文就FMO3结构、功能及其基因多态性与药物代谢和疾病的关系进行综述。

Flavin-containing monooxygenase 3 （ FMO3 ） is an important hepatic microsomal enzyme that oxidizes a number of drugs, xenobiotics and other chemicals. Many variants in the gene encoding FMO3 have been identified, some of which result in altered enzymatic activity, consenquently, altered substrate metabolism. Studies also implicate individual and ethnic differences in FMO3. Thus ,it is anticipated that knowledge regarding functionally-relevant FMO3 genetic variability will become increasingly important for drug development and patient therapeutic choices.