摘要
高尿酸血症和痛风的发生是遗传和环境因素相互作用的结果,其中遗传性因素近年来尤其得到广泛的关注。导致高尿酸血症和痛风的主要遗传性因素包括嘌呤代谢过程中关键酶的缺乏、遗传性肾脏功能障碍和其他遗传代谢病。该文主要从以上3方面对遗传性因素导致的高尿酸血症及痛风的研究进展进行综述,并对该疾病研究的发展趋势进行展望。
The occurrence of hyperuricemia and gout is induced by the interaction of genetic and environmental factors, and the former one is especially concerned in recent years. Studies suggested that several factors, which mainly consisted of the deficiency of pivotal enzymes involved in purine metabolism, mutations in kidney and other genetic metabolic diseases, contribute to the aceurence of hyperuricemia and gout. In this paper,recent advance in the study of hereditary factors of hyperuricemia and gout is reviewed and the trend of diagnosis and prevention for hyperuricemia and gout is also prospected.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第10期1265-1268,共4页
Chinese Pharmacological Bulletin
基金
国家重点基础研究发展计划(973计划)资助项目(No2007CB511903)
国家自然科学基金资助项目(No90709045)
国家“十一五”科技支撑计划资助项目(No2006BAI08B04-01)
