Ki-67、MMP-9蛋白表达与垂体腺瘤侵袭性的相关性研究

Expressions of Ki-67 and MMP-9 and their relationship with the invasiveness in pituitary adenomas

目的检测细胞核内增殖抗原Ki-67与基质金属蛋白酶-9（MMP-9）在侵袭性、非侵袭性及复发垂体腺瘤中的表达，探讨其与垂体腺瘤侵袭性及肿瘤复发的相关性。方法免疫组化SP法对86例垂体腺瘤患者标本的Ki-67、MMP-9的表达进行检测。结果侵袭性垂体腺瘤的Ki-67、MMP-9蛋白表达明显高于非侵袭性垂体腺瘤（P〈0．01）；侵袭性腺瘤复发组Ki-67、MMP-9蛋白表达明显高于侵袭性腺瘤非复发组（P〈0．01），且Ki-67、MMP-9蛋白在垂体腺瘤中表达呈正相关。结论Ki-67、MMP-9蛋白表达增高与侵袭性垂体腺瘤的发生及术后复发存在相关性，且两者在垂体腺瘤的侵袭性生长中可能起协同作用。

Objective To investigate the expressions of Ki-67 and MMP-9 in patients with invasive ,noninvasive and recurrent pituitary adenomas, respectively and to evaluate the relationship between the expression of Ki-67 and MMP-9 in the invasion and recurrence of pituitary, adenomas. Methods The expressions of Ki-67 and MMP-9 were detected in 86 pituitary adenomas by using immunohistochemical s-p assay. Results Compared with the non-invasive pituitary adenomas, the expressions of Ki-67 and MMP-9 increased significantly in invasive ones （ P 〈 0.01 ） ; Compared with the non-recurrent cases in invasive pituitary adenomas, the expressions of Ki-67 and MMP-9 increased strikingly in recurent invasive ones （ P 〈 0.01 ）. There was a positive correlation between Ki-67 and MMP-9 at protein level. Conclusion The increased expressions of Ki-67 and MMP-9 are associated with the invasiveness and recurrence of pituitary adenomas, and they might have a synergetic effect in the invasive growth of pituitary adenomas.