家兔动脉粥样硬化早期超声检测方法的对比研究

Comparative research on early detection of atherosclerosis in rabbits by ultrasound

目的比较脉冲多普勒(PD)技术和血管回声追踪(ET)技术检测家兔腹主动脉粥样硬化早期的价值。方法48只雄性日本大耳白兔随机分为对照组和实验组。实验组以高脂饲料喂养建立动物模型,于喂养后第4,8,12周末测量腹主动脉阻力指数(RI)、搏动指数(PI)、弹性指数(Ep)、僵硬度(β)和顺应性(AC)。结果实验组4周末AC减低,与对照组比较,差异具有统计学意义(P<0.05);8周末Ep和β增高,差异有极显著意义(P<0.01);12周末RI、PI增高,差异有统计学意义(P<0.05)。结论ET与PD技术相比,ET可以更早地检测动脉粥样硬化的早期表现。

Objective To compare the value of pulse Doppler（PD） and echo- tracking（ET） technique in early detection of abdominal aorta atherosclerosis in rabbits. Methods Forty- eight male rabbits were randomly divided into control group and experimental group. The experimental group rabbits were fed with hyperliposis animal diet. At the end of 4th, 8th and 12th week, RI, PI, Ep, β and AC were measured. Results At the end of 4th week, AC was decreased; at the end of 8th week, Ep and β were increased （P 〈 0.01 ）, at the end of 12th week, RI and PI were increased （P 〈 0.05）, there were significant differences between two groups. Conclusion Compared with PD, ET can detect atherosclerosis earlier.