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胰岛素样生长因子1在原发性高血压中的研究进展 被引量:5

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摘要 胰岛素样生长因子1(Insulin—like growth factor,IGF-1)是人体内的一种重要的细胞因子,属于胰岛素家族的一种多肽。通过与特异性受体结合,发挥重要的生理功能。近年来,随着IGF-1与心血管疾病关系研究的深入,人们注意到IGF-1与许多心血管疾病密切相关,能够促进心脏的生长发育,增强心脏功能,抑制心肌细胞凋亡,而且还有促进心肌细胞肥大,参与高血压左心室肥厚(LVH)形成的作用。现就1GF-1与原发性高血压(EH)的关系作一综述。
出处 《中华高血压杂志》 CAS CSCD 北大核心 2008年第10期875-877,共3页 Chinese Journal of Hypertension
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参考文献27

  • 1[1]Jiang X,Srinivassan S R,Dalferes E R,et al.Plasma insulin-like growth factor 1 distribution and its relation to blood pressure in adolescents:the Bogalusa Heart Study[J].Hypertension,1997,10:714-719.
  • 2[3]Donohue TJ,Dwotkin LD,Langa MN,el at.Induction of myocardial insulin-like growth factor-1 gene expression in left ventricular hypertrophy[J].Circulation,1994,89:799-809.
  • 3[4]Tbrrado J,Carraseosa C.Phannaeological characteristies of Parenteral IGF-1 administration[J].Curr Pham Biotechnol,2003,4:123-140.
  • 4[5]Foncea R,Andersson M,Ketterman A,et al.Insulin-like growth factor-1 activates multiple signal transduction pathways in cultured rat cardiac myocytes[J].J Biol Chem,1997,272:19115-19124.
  • 5漆正堂.胰岛素样生长因子结合蛋白-3[J].生命的化学,2003,23(2):102-105. 被引量:15
  • 6[7]Okazaki K,Jingushi S,Ikenoue T,et al.Expression of parathyroid hormone-related peptide and insulin-like growth factor 1 during rat fracture healing[J].J Orthop Res,2003,21:511-520.
  • 7[8]Clemmons DR,Moses AC,Mckay MJ,et al.The combination of insulin-like growth factor 1 and insulin-like growth factor binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes:evidence for in vivo biological activity[J].J Clin Endocrinol Metab,2000,85:1518-1524.
  • 8李灏,何建国.IGF-Ⅰ对心力衰竭的作用及可能机制[J].现代诊断与治疗,2004,15(3):158-162. 被引量:8
  • 9[10]Cheng W,Reiss K,Kajstura J,et al.Down-regulation of the IGF-1 system parallels the attenuation in the proliferative capacity of rat ventricular myoctes during postnatal development[J].Lab Invest,1995,72:646-655.
  • 10[11]Freestone NS,Ribaric S,Mason WT.The effect of insulin like growth factor-1 on adult rat cardiac contractility[J].Mol Cell Biochem,1996,163-164:223-229.

二级参考文献111

  • 1李光伟,Step.,L.检测人群胰岛素敏感性的一项新指数[J].中华内科杂志,1993,32(10):656-660. 被引量:2125
  • 2曹国良,乔永芳,戴蓉芳.中美欧高血压指南之比较[J].医学与哲学,2005,26(5):46-47. 被引量:43
  • 3姜坚.赖诺普利与氯沙坦治疗心力衰竭对心室重构的影响[J].实用诊断与治疗杂志,2005,19(12):876-878. 被引量:7
  • 4Van EM, Vetter H, Grohe C. Angiotensin-converting enzyme inhibitor(ACE) inhibition attenuates insulin-like growth factorI (IGF-Ⅰ) induced cardiac fibroblast proliferation [J ]. British Journal of Pharmacology,2000,131: 1592-1596.
  • 5Marijke B, Jacqueline CS, Russ P, et al. Angiotensin Ⅱ stimulates gene expression of cardiac insulin-like growth factor-1 and its receptor through effects on blood pressure and food intake [J]. Hypertension, 1999,34:1053-1059.
  • 6LeRoith D, Werner H, Beither-Johmson D, et al. Molecular and cellular aspects of the insulin-like growth factor-1 receptor [J]. Endocr Rev,1995,16:143-163.
  • 7Patrick D, Marjike B, Jie Du. Angiotensin Ⅱ modulation insulin-like growth factor-1 expression in the cardiovascular system [J]. Thrend Cardiovasc Med,1996,6:187-196.
  • 8Haddad GE, Blackwell E, BikhaziA. Regulation of insulin-like growth factor-1 by the rennin-angiotensin system during regression of cardiar eccentric hypertrophy through angiotensin-converting enzyme inhibitor and AT1 antagonist[J]. Can J Physiol Pharmarol, 2003,81 : 142-149.
  • 9Delafontaine P, Brink M. The hormone and insulin-like growth factor-1 axis in heart failure [J]. Endoerinol (Paris), 2000,61:22-26.
  • 10Donohue TJ, Dworkin LD, Ma J, et al. Antihypertensive agents that limited ventricular hypertrophy inhibit cardiac expression of insulin-like growth factor-1[J]. J Invest Med, 1997,45:584-591.

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