摘要
目的探讨中心动脉压与冠脉病变程度的相关性。方法连续选取行冠脉造影且左室射血分数>50%的冠心病患者204例,分为单支病变组、两支病变组、三支病变组,采用有创和无创测量法分别测中心动脉和外周动脉收缩压(SBP)和舒张压(DBP),比较中心动脉压与冠脉病变的关系。结果单支病变组、两支病变组、三支病变组外周动脉 SBP、脉压(PP)和中心动脉 SBP、PP、收缩压分数(FSP=SBP/平均动脉压,MAP)随冠脉病变支数的增加而增加,中心动脉舒张压分数(FDP=DDB/MAP)随冠脉病变支数的增加而降低(P 均<0.05)。Logistic 回归示:年龄、糖尿病、中心动脉 FSP、PP 的升高以及中心动脉 FDP 的降低与冠心病三支病变的危险性相关[FSP(每增加0.1),OR=1.164,95%CI=1.102~1.476;PP(每增加10 mmHg),OR=1.185;95%CI=1.151~1.237;FDP(每下降0.1),(OR=0.933,95%CI=0.903~0.975,P 均<0.01]。结论年龄、糖尿病、中心动脉 FSP、PP 的升高以及 FDP 的降低是冠心病三支病变的危险因素。
Objective To investigate the relationship between central blood pressure and the severity of coronary artery disease. Methods Consecutive 204 patients with coronary artery disease were enrolled. All patients were echocardiographically confirmed ejection fraction 〉50%. The patients were categorized into as: one-, two-, and three-vessels coronary artery disease group. Central aortic SBP and DBP was measured by cathetarization during angiography of coronary artery and brachial blood pressure was measured using cuff method. Results Peripheral SBP, PP and ascending aortic SBP, PP, fractional systolic pressure(FSP= SBP/MAP) were increased and ascending aortic fractional diastolic pressure (FDP= DBP/MAP) was reduced when the diseased coronary vessels were increased(P〈0.05 ). Multivariable logistic analysis showed: Age, diabetes mellitus, increased ascending aortic PP, FSP, and reduced FDP were prediposed risk factors for three-vessel coronary artery disease (FSP per increase O. 1, OR=1. 142, 95%CI=1. 032-1. 452; PP per increase 10 mmHg, OR=1. 195, 95%CI:1. 151-1. 237; FDP per decrease 0. 1, OR=0.933, 95% CI 0.903-0.975), (P all 〈0.01). Conclusion Age, diabetes mellitus, increased ascending aortic PP, FSP, and reduced FDP which become a predispose risk factors for three vessel coronary artery disease.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2008年第10期881-884,共4页
Chinese Journal of Hypertension
关键词
中心动脉压
收缩压分数
舒张压分数
脉压
冠心病
Central aortic pressure
Fractional systolic pressure
Fractional diastolic pressure
Pulse pressure
Coronary artery disease