期刊文献+

中心动脉压与冠脉病变程度的相关性 被引量:16

Central Blood Pressure and the Extent of Coronary Artery Disease
下载PDF
导出
摘要 目的探讨中心动脉压与冠脉病变程度的相关性。方法连续选取行冠脉造影且左室射血分数>50%的冠心病患者204例,分为单支病变组、两支病变组、三支病变组,采用有创和无创测量法分别测中心动脉和外周动脉收缩压(SBP)和舒张压(DBP),比较中心动脉压与冠脉病变的关系。结果单支病变组、两支病变组、三支病变组外周动脉 SBP、脉压(PP)和中心动脉 SBP、PP、收缩压分数(FSP=SBP/平均动脉压,MAP)随冠脉病变支数的增加而增加,中心动脉舒张压分数(FDP=DDB/MAP)随冠脉病变支数的增加而降低(P 均<0.05)。Logistic 回归示:年龄、糖尿病、中心动脉 FSP、PP 的升高以及中心动脉 FDP 的降低与冠心病三支病变的危险性相关[FSP(每增加0.1),OR=1.164,95%CI=1.102~1.476;PP(每增加10 mmHg),OR=1.185;95%CI=1.151~1.237;FDP(每下降0.1),(OR=0.933,95%CI=0.903~0.975,P 均<0.01]。结论年龄、糖尿病、中心动脉 FSP、PP 的升高以及 FDP 的降低是冠心病三支病变的危险因素。 Objective To investigate the relationship between central blood pressure and the severity of coronary artery disease. Methods Consecutive 204 patients with coronary artery disease were enrolled. All patients were echocardiographically confirmed ejection fraction 〉50%. The patients were categorized into as: one-, two-, and three-vessels coronary artery disease group. Central aortic SBP and DBP was measured by cathetarization during angiography of coronary artery and brachial blood pressure was measured using cuff method. Results Peripheral SBP, PP and ascending aortic SBP, PP, fractional systolic pressure(FSP= SBP/MAP) were increased and ascending aortic fractional diastolic pressure (FDP= DBP/MAP) was reduced when the diseased coronary vessels were increased(P〈0.05 ). Multivariable logistic analysis showed: Age, diabetes mellitus, increased ascending aortic PP, FSP, and reduced FDP were prediposed risk factors for three-vessel coronary artery disease (FSP per increase O. 1, OR=1. 142, 95%CI=1. 032-1. 452; PP per increase 10 mmHg, OR=1. 195, 95%CI:1. 151-1. 237; FDP per decrease 0. 1, OR=0.933, 95% CI 0.903-0.975), (P all 〈0.01). Conclusion Age, diabetes mellitus, increased ascending aortic PP, FSP, and reduced FDP which become a predispose risk factors for three vessel coronary artery disease.
出处 《中华高血压杂志》 CAS CSCD 北大核心 2008年第10期881-884,共4页 Chinese Journal of Hypertension
关键词 中心动脉压 收缩压分数 舒张压分数 脉压 冠心病 Central aortic pressure Fractional systolic pressure Fractional diastolic pressure Pulse pressure Coronary artery disease
  • 相关文献

参考文献7

  • 1欧阳茂,杨侃,蒋卫红,匡建华,曹宇,张志辉,李静乐,彭丽萍,张梦玺.培哚普利及美托洛尔对中心动脉压的作用[J].中华高血压杂志,2007,15(1):30-33. 被引量:6
  • 2王宏宇,胡大一,马志敏,冯存民,张杰,邓素,张瑞爽,李运田,刘文玲,赵明中,许玉韵.脉压与冠状动脉病变严重性的关系研究[J].中华心血管病杂志,2003,31(2):83-86. 被引量:128
  • 3[3]Stanley SF,Shehzad AK,Nathan DW,et al.Is pulse pressure useful in predicting risk for coronary heart disease[J].Circulation,1999,100:354-360.
  • 4[4]Weber T,Auer J,O'Rourke MF,et al.Increased arterial wave reflection predict severe cardiovascular events in patients undergoing percutaneous coronary interventions[J].Eur Heart J,2005,26:2657-2663.
  • 5[5]Morgan T,Lauri J,Bertram D,et al.Effect of different antihypertensive drug classes on central aortic pressure[J].Am J of Hypertension,2004,17:118-123.
  • 6[6]Roman MJ,Kizer JR,Ali T,et al.Central blood pressure better predicts cardiovascular events than does peripheral blood pressure:The STRONG heart study[J].Circulation,2005,112(Suppl 2):778.
  • 7[7]Davies JI,Band MM,Pringle S.Peripheral blood pressure measurement is as good as applanation tonometry at predicting ascending aortic blood pressure[J].J Hypertens,2003,21:571-576.

二级参考文献15

  • 1苏海.重视血压测量的规范操作[J].高血压杂志,2005,13(10):597-599. 被引量:34
  • 2蒋雄京,李秋英,张宇清,刘国仗,刘力生.依那普利与吲哒帕胺对高血压患者中心和外周动脉压的影响[J].中华心血管病杂志,2005,33(10):885-888. 被引量:10
  • 3[2]Nichols WW,O'Rourk EM.McDonald's Blood flow in arteries.Theoretical,experimental and clinical principles[M].4th ed.London:ArnoldE.Publish,1998,54-401.
  • 4[5]Stolt M,Sjonell G,Astrom H,et al.Factors affecting the validity of the standard blood pressure cuff[J].Clin Physiol,1993,13:611-620.
  • 5[6]Safar ME,Levy BI,Struijker-Boudier H.Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases[J].Circulation,2003,107:2864-2869.
  • 6[7]Mitchell GF.Arterial stiffness and wave reflection in hypertension:pathophysiologic and therapeutic implications[J].Curt Hypertens Rep,2004,6:436-441.
  • 7[8]Williams B,Lacy PS,Thom SM,et al.Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes:principal results of the conduit artery function evaluation(CAFe) study[J].Circulation,2006,113:1213-1225.
  • 8[9]Chirinos JA,Zambrano JP,Chakko S,et al.Aortic pressure augmentation predicts adverse cardiovascular events in patients with established coronary artery disease[J].Hypertension,2005,45:980-985.
  • 9[10]Nurnberger J,Keflioglu-scheiber A,Opazo Saez AM,et al.Augmentation index is associated with cardiovascular risk[J].Hypertension,2002,20 (12):2407-2414.
  • 10[11]Wing LM,Reid CM,Ryan P,et al.A comparison of outcomes with angiotensin converting enzyme inhibitors and diuretics for hypertension in the elderly[J].N Engl J Med,2003,348:583-592.

共引文献132

同被引文献146

引证文献16

二级引证文献61

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部