含有环丙沙星高分子前药物的合成

Synthesis of Ciprofloxacin-Bonded Polymer Prodrug

以抗菌药物-盐酸环丙沙星(CIPRO)代替传统的聚氨酯扩链剂,采用六亚甲基二异氰酸酯(HDI)、聚己内酯(PCL)为原料,通过典型的两步聚氨酯缩合反应,成功地将药物耦合到聚氨酯的骨架结构上,合成了环丙沙星-聚氨酯高分子前药物。研究了不同加料顺序对药物含量和平均分子量的影响。结果表明,合成的高分子前药物具有较高的药物含量、平均分子量和较窄的分散性。

Antibiotic drug, ciprofloxacin hydrochloride which replaces the traditional chain extender, has been successfully incorporated as a monomer into the polyurethane backbone structure via a classical two-step polyurethane condensation reaction with 1,6-hexane diisocyanate （HDI） and polycaprolactone diol （PCL）. The sequential order of monomer feeding have been studied. The result shows the polyurethane-ciprofloxacin prodrug have high drug concentration, molecular weight and a relatively narrow polydispersity.