胃癌患者血清VEGF、MMP-2的表达及其与浸润和转移的关系

Expression of Serum VEGF and MMP-2 in Gastric Carcinoma and its Relationship with Invasion and Metastasis

[目的]探讨胃癌患者血清VEGF及MMP-2的表达与胃癌浸润和转移的关系。[方法]应用ELISA法检测69例胃癌患者血清VEGF、MMP-2的表达水平,并分析其与临床病理因素间的关系。[结果]低分化胃癌患者血清VEGF阳性率(64.0%)显著高于高、中分化者(36.8%,P<0.05);且VEGF、MMP-2表达与肿瘤的浸润深度、淋巴结转移、远处转移及TNM分期均密切相关(P<0.05)。胃癌患者血清VEGF的阳性表达与MMP-2的阳性表达呈正相关(rs=0.322,P<0.01)。[结论]VEGF和MMP-2在胃癌的浸润和转移中起重要作用,血清VEGF、MMP-2的表达水平可作为了解胃癌生物学行为和判断预后的指标。

[Purpose] To investigate the relationship of VEGF and MMP-2 expression with invasion and metastasis in gastric earcinoma. [Method] Expression of VEGF and MMP-2 in 69 cases with gastric carcinoma was detected by ELISA method and its relationship with clinical pathological factor was analyzed. [Results] Serum VEGF positive expression rate in low differentiation patients （64.0%） was significantly higher than that in morderate, high differentiation patients （36.8%） （P〈0.05）. Serum VEGF and MMP-2 expression level was significantly associated with depth of invasion, lymph node metastasis, distant metastasis and TNM stage（P〈0.05）. Positive correlation was found between the posi- tive expression of serum VEGF and MMP-2（rs=0.322,P〈0.01）. [Conclusion] VEGF and MMP-2 play important role in invasion and metastasis of gastric carcinoma. The expression level of serum VEC, F and MMP-2 is helpful for evaluation of the biological behavior and prognosis of gastric carcinoma.