血清叶酸与宫颈癌发病关系的Meta分析

META-ANALYSIS OF THE RELATIONSHIOP BETWEEN SERUM FOLIC ACID STATUS AND THE RISK OF CERVICAL CANCER

[目的]探讨血清叶酸水平和宫颈癌发病之间的关系。[方法]检索1990年1月～2007年7月公开发表的有关叶酸和宫颈癌发病关系的研究文献,使用Meta分析专用软件RevMan4.2对纳入的5篇文献进行定量分析。[结果]纳入文献累计病例779个、累计对照1374个。按四分位数将血清叶酸水平分为四个等级,低于最高四分位数Q1者视为叶酸水平低,病例组和对照组之间的差异有统计学意义(P﹤0.05),OR值为1.84,95%CI(1.03,3.29);进一步对四个等级进行亚组分析,发现随着叶酸水平降低,患宫颈癌的危险性增加,血清叶酸水平等级最低(Q4),病例组和对照组之间的差异有统计学意义(P﹤0.05),OR值为2.41,95%CI为(1.13,4.9)。[结论]血清叶酸水平低可能增加宫颈癌的发病风险。

[ Objective] To explore the relationship between serum folic acid status and the risk of cervical cancer. [ Methods] The literature about the association of relic acid and cervical cancer from January of 1990 to July of 2007 ware searched for according to inclusion and exclusion criteria. The data in the 5 studies selected were analyzed by RevMan 4.2 software： [ Results] The cumulative cases and controls were 779 and 1 374 in 5 studies, respectively. In low serum relic acid levels （ 〈 Q1 ）, it showed significant differences between cases and controls （OR= 1.84, 95%CI=1.03, 3.29）. There were significandy increasing trend in the risk of cervical cancer with reducing level of serum fohc acid in the subgroup analysis. It showed there were statistical differences between cases and controls in lowest quartile of serum relic acid group （OR=2.41, 95%CI= 1.13, 4.9）. [Conclusion] Low serum relic acid status is associated with increased cervical cancer risk.