影响胃肠间质瘤根治术患者预后因素的分析:附术后5年97例报告

Prognostic factor analysis of patients with gastrointestinal stromal tumor undergoing radical operation over 5 years:a report of 97 cases

目的探讨影响胃肠道间质瘤手术患者预后的因素。方法回顾性分析有完整临床资料和随访5年以上的97例胃肠道间质瘤根治术后患者。结果单因素分析结果显示患者性别、肿瘤部位、肿瘤大小、肿瘤细胞类型、肿瘤有无坏死、核分裂相数目及术后是否使用Gleevec辅助治疗与患者的预后具有相关性。应用COX回归模型分析显示肿瘤部位、肿瘤大小、肿瘤细胞类型、肿瘤有无坏死、核分裂相数目,及术后是否使用Gleevec辅助治疗是影响胃肠道间质瘤根治术患者预后的独立因素。结论肿瘤部位、肿瘤大小、肿瘤细胞类型、肿瘤有无坏死、核分裂相数目及Gleevec治疗是影响胃肠道间质瘤根治术患者预后的重要指标。

Objective To analyze the independent factors affecting the prognosis of gastrointestinal stromal tumor （GIST） patients undergoing radical operation. Methods The clinical characteristics and follow up data of the 97 patients with GIST underwent radical opsration from January, 2001 to January, 2003 in our hospital were retrospectively analyzed by univariate and multivariate methods. Results In the univariate analysis of the 97 cases, gender, tumor location, tumor size, tumor cell type, necrosis, mitotic count, and Gleevec administration postoperatively were found to be related to the prognosis of GIST. Multivariate Cox model analysis showed that tumor location, tumor size, tumor cell type, necrosis, mitotic count, and Gleevec administration postoperatively were independent prognostic factors for patients with GIST. Conclusions Tumor location, tumor size, tumor cell type, necrosis, mitotic count are important prognostic factors for patients with GIST undergoing radical operation.