肝肠-钙黏蛋白——一种新的胃腺癌标记物
摘要
LI-cad在结构和功能上不同于其它经典钙黏着蛋白,在正常组织中选择性地表达于小肠与大肠上皮细胞和杯状细胞的基底外侧区表面,鼠类还表达于肝细胞膜。它是对肠黏膜上皮细胞中经典钙黏蛋白和桥粒钙黏蛋白功能的补充。笔者就其结构、功能及其与胃癌的关系作一综述。
出处
《中国普通外科杂志》
CAS
CSCD
2008年第10期1010-1012,共3页
China Journal of General Surgery
参考文献24
-
1Overduin M, Harvey TS, Bagby S, et al. Solution structure of the epithelial cadherin domain responsible for selective cell adhesion [ J ]. Science, 1995, 267 ( 5196 ) : 386 -390.
-
2袁伟杰,陈志康,伍绍斌,葛杰,胡斌,陈子华.EphA2和E-cadherin在胃癌中的表达及其意义[J].中国普通外科杂志,2008,17(4):397-399. 被引量:4
-
3吴泽宇,万进,杜嘉林,赵刚,姚远,刘全芳,彭林,王志度,黄炽明,杨珏.中下段直肠癌E-钙黏附素表达与淋巴结微转移的关系研究[J].外科理论与实践,2007,12(4):373-375. 被引量:1
-
4Wendeler MW, Jung R, Himmel- bauer H, et al. Unique gene structure and paralogy define the 7 D- cadherin family [ J ]. Cell Mol Life Sci, 2006, 63 ( 13 ) : 1564 - 1573.
-
5Kremmidiotis G, Baker E, Crawford J, et al. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity [ J ] . Genomics, 1998,49(3) :467 -471.
-
6Crosier PS, Bardsley A, Horsfield JA, et al. An in situ hybridization screen in zebrafish for the selection of genes encoding secreted proteins [ J ]. Dev Dyn, 2001, 222 (4) :637 -644.
-
7Wendeler MW, Drenckhahn D, Gessner R, et al. Intestinal LI-cadherin acts as a Ca2 + - dependent adhesion switch [ J ]. J Mol Biol,2007,370(2) :220- 230.
-
8Grotzinger C, Kneifel J, Patschan D, et al. LI-cadherin : a marker of gastric metaplasia and neoplasia. [J]. Gut, 2001,49(1) :73 - 81.
-
9Jung R, Wendeler MW, Danevad M, et al. Phylogenetic origin of LI- cadherin revealed by protein and gene structure analysis [ J ] . Cell Mol Life Sci,2004,61 ( 10): 1157 -1166.
-
10Bremnes RM, Veve R, Gabrielson E, et al. High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non- small- cell lung cancer [ J ]. J Clin Oncol, 2002,20(10) :2417 - 2428.
二级参考文献18
-
1冯延平,黄涛,高军,常青,秦仁义.EphA2与E-cadherin在胰腺癌中的表达及其意义[J].中国普通外科杂志,2005,14(12):914-917. 被引量:8
-
2顾晋.美国NCCN直肠癌治疗规范(2006)解读[J].中国实用外科杂志,2006,26(12):902-906. 被引量:12
-
3蒋萍,李景和,罗庚求,沈明,刘洁,李红玲.大肠癌组织中EphA2,VEGF和MMP9蛋白的表达及其相关性研究[J].中国普通外科杂志,2007,16(7):696-699. 被引量:4
-
4Siewert JR,Kestlmeier R,Busch R,et al.Benefits of D2 lymph node dissection for patients with gastric cancer and pNO and pN1 lymph node metastases[J].Br J Surg,1996,83(8):1144-1147.
-
5Noura S,Yamamoto H,Ohnishi T,et al.Comparative detection of lymph node micrometastases of stage Ⅱ colorectal cancer by reverse transcriptase polymerase chain reaction and immunohistochemistry[J].J Clin Oncol,2002,20(20):4232-4241.
-
6Palma RT,Waisberg J,Bromberg SH,et al.Micrometastasis in regional lymph nodes of extirpated colorectal carcinoma:immunohistochemical study using anti-cytokeratin antibodies AE1/AE3[J].Colorectal Dis,2003,5 (2):164-168.
-
7Takayama O,Yamamoto H,Ikeda K,et al.Application of RT-PCR to clinical diagnosis of micrometastasis of colorectal cancer:A translational research study[J].Int J Oncol,2004,25(3):597-604.
-
8Bendardaf R,Elzagheid A,Lamlum H,et al.E-cadherin,CD44s and CD44v6 correlate with tumour difierentiation in colorectal cancer[J].Oncol Rep,2005,13(5):831-835.
-
9Hori H,Fujimori T,Fujii S,et al.Evaluation of tumor cell dissociation as a predictive marker of lymph node metastasis in submucosal invasive colorectal carcinoma[J].Dis Colon Rectum,2005,48(5):938-945.
-
10Saito T,Masuda N,Miyazaki T,et al.Expression of EphA2 and E-cadhefin in colorectal cancer:correlationwith cancer metastasis[J].Oncol Rep,2004,11(3):605-611.
共引文献3
-
1管宏俊,陈云琦,孙长鹏,纪洁.EphA2和E-cad在非小细胞肺癌中的表达及其临床病理学意义[J].牡丹江医学院学报,2013,34(1):5-9. 被引量:2
-
2纪红.子宫内膜样腺癌中具有IQ结构域的人RasGTP激活蛋白相关蛋白1和E-cadherin的表达及临床意义[J].中国老年学杂志,2018,38(2):358-360. 被引量:1
-
3金响国,孙向东,胡凯,李兴江,张丽艳,许景伟,王莹颖.EphA2在胃癌中的表达及临床病理学意义[J].中国老年学杂志,2014,34(16):4562-4563. 被引量:3
-
1王宾,周崇治,唐华美,王权,温玉刚,于振海.肝肠钙黏蛋白在胃癌中的表达及其与患者预后的关系[J].中华实验外科杂志,2011,28(5):714-716. 被引量:5
-
2谷翠华,尚国臣,李睿,田书信,陈卫刚,郑勇.肝肠钙黏蛋白在新疆哈萨克族、汉族胃腺癌中的表达及意义[J].世界华人消化杂志,2014,22(9):1280-1284. 被引量:1
-
3郑正,牛建华.胃癌发生中的独特肿瘤标记物—LI-cadherin[J].现代生物医学进展,2010,10(12):2391-2393. 被引量:1
-
4向军,黄奕华,崔冀,黄美近,王磊,汪建平.同期肝切除治疗结直肠癌同时性肝转移[J].中华普通外科杂志,2007,22(7):507-509. 被引量:4
-
5向军,黄奕华,黄美近,王磊,杨祖立,彭俊生,汪建平.同时性结直肠癌肝转移同期肝切除预后因素分析[J].中国实用外科杂志,2009,29(S1):52-54.
-
6吴巧斌,王飞,李建国.肝肠钙黏着蛋白的表达与消化系统肿瘤关系的研究现状[J].医学综述,2016,22(12):2292-2295. 被引量:3
-
7杨峰.超声和CT对术前甲状腺乳突状癌颈部转移淋巴结的评价[J].黑龙江医学,2014,38(7):758-761. 被引量:2
-
8牛建华,刘仕琪,彭心宇,木拉提,秦江梅,曹祝萍.胃癌及癌前病变中肝肠钙黏蛋白的表达及其意义[J].中华普通外科杂志,2008,23(6):444-446. 被引量:2
-
9李纪良,林来兴妹,欧阳明辉,巢穗,彭一兵,常文生,李英杰.鼠类亲本瘤细胞体外生长时需要胆固醇[J].第一军医大学学报,1991,11(1):1-5.
-
10曹卫东,章翔,刘飞,刘卫平,王占祥.鼠类双微体2癌基因、P53蛋白与星形细胞瘤的预后[J].解放军医学杂志,1999,24(5):348-350.