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转化生长因子β受体与肿瘤的研究新进展 被引量:1

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摘要 TGF-β作为一种有效地负性调控人体多种上皮细胞的因子,通过抑制TβRⅡ与TβRⅠ,TGF-β的结合,阻断了TGF-β1/Smads信号转导,使细胞生长失控,恶变机率增加;同时,转化生长因子受体表达低下,使肿瘤细胞逃避TGF-β1介导的生长抑制效应,从而导致了肿瘤的发生发展。笔者就TGF-βR与肿瘤研究文献作一综述。
出处 《中国普通外科杂志》 CAS CSCD 2008年第10期1016-1018,共3页 China Journal of General Surgery
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参考文献18

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二级参考文献29

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