术后残存垂体腺瘤的伽玛刀治疗

Gamma Knife for Residual Pituitary Adenomas After Surgery

目的探讨垂体腺瘤术后残存患者伽玛刀治疗的有效性和安全性。方法回顾性分析2005年5月至2007年7月接受伽玛刀治疗并获得完整随访的52例垂体腺瘤术后残存患者的临床资料,随访期6～26个月,平均14.4个月。结果肿瘤控制率达94.2%(49/52),激素水平下降率73.9%(17/23),出现垂体功能低下7例,其中甲状腺功能低下3例,性功能低下2例,肾上腺皮质功能减退1例、生长激素缺乏1例,发生率分别为5.8%、3.8%、1.9%、1.9%。1例患者出现视野缺损加重,发生率为1.9%。无死亡病例。结论伽玛刀治疗术后残存的垂体腺瘤安全有效,并发症少。

Objectives To evaluate the curative effect of gamma knife on residual pituitary adenomas after surgery and its safety. Methods The clinical data of 52 patients with residual pituitary adenomas after surgery, who were treated by gamma knife from May, 2005 to July, 2007, were analyzed retrospectively. All the patients were followed up from 6 to 26 months （mean, 14.4 months）. Results The control rate of the pituitary adenomas were 94.2% （49/52）. A significant decrease or normalization of excessive hormone was observed in 73.9%（17/23） of the patients. The complications after gamma knife included hypopituitarism （7 patients）, hypothyroidism （3 patients）, hypogonadism （2 patients）, hypoadrenocorticism （1 patients） and deficiency of growth hormone （1 patients）. Conclusions Gamma knife for residual pituitary adenomas after surgery is effective and safe, and ,nay cause a few complications.