扩张型心肌病患儿血清PⅠCP、PⅢNP检测及意义被引量：1

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摘要检测38例扩张型心肌病(DCM)患儿(观察组)和36例正常儿童(对照组)血清Ⅰ型、Ⅲ型前胶原羧基端肽(PⅠCP,PⅢNP)水平,并用超声心动图行心功能检测。结果与对照组比较,观察组血清PⅠCP、PⅢNP水平明显升高(P<0.05),心功能EF值、E/A显著降低(P均<0.05);血清PⅠCP、PⅢNP水平与EF值、E/A值呈显著负相关(r分别为-0.79、-0.72、-0.77、-0.77,P均<0.01)。认为血清PⅠCP、PⅢNP水平可用于评价DCM患儿心肌纤维化及心脏功能状况。

作者郭春艳王明月徐竹梅冯娟

机构地区山东中医药大学第二附属医院山东省立医院

出处《山东医药》 CAS 北大核心 2008年第29期56-57,共2页 Shandong Medical Journal

关键词扩张型心肌病前胶原羧基端肽心肌纤维化心功能

分类号 R542.2 [医药卫生—心血管疾病]

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1Pauschinger M, Doernrer A, Remppis A ,el al. Diferential myocardial abundance of collagen type Ⅰ and type Ⅲ mRNA in dilated cardiomyopathy effect of myocardial inflammation [ J]. Cardiovasc Res, 2000,37(9) :123-129.
2陆盈,徐芳,肖沪生,银浩强,李勇进.Tei指数评价舒张性心力衰竭的价值[J].上海医学影像,2007,16(2):97-98. 被引量：4
3武利军,赵连友,郑强荪,徐焰,马福臣.心肌纤维化患者血清细胞外基质的变化及其临床意义[J].临床心血管病杂志,2006,22(1):18-20. 被引量：11

二级参考文献15

1[1]Diez J,Laviades C,Mayor G.Increased serum concentrations of procollagen peptides in essential hypertension.Relation to cardiac alterations.Circulations,1995,1; 91 (5):1450-1456
2[3]Senni M,Tribouilloy CM,Rodeheffer RJ,et al.Congestive heart failure in the community:a study of all incident cases in Olmsted County,Minnesota,in 1991.Circulation,1998,98(21):2282-2289
3[4]Kitzman DW,Gardin JM,Gottdiener JS,et al.Importance of heart failure with preserved systolic function in patients ＞ or = 65 years of age.CHS Research Group.Cardiovascular Health Study.Am J Cardiol,2001,87(4):413-419
4[5]Vasan RS,Larson MG,Benjamin EJ,et al.Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction:prevalence and mortality in a population-based cohort.J Am Coll Cardiol,1999,33(7):1948-1955
5[6]Tei C.New non-invasive index for combined systolic and diastolic ventricular function.J Cardiol,1995,26 (2):135-136
6WEBER K T, SUN Y, TYAGI S C. Collagen network of the myocardium: function Structural remodeling and regulatory mechanism [J]. Mol Cell Cardiol,1994, 26:279-92.
7KHAGHANI A,SEYMOUR A M,YACOUB M H,et al. Dynamic role of extracellular matrix metalloproteinases in heart failure[J]. Cardiovasc Pathol, 1998,7:153-159.
8SUN Y,WEBER K T. Infarct scar: a dynamic tissue[J]. Cardiovasc Res, 2000,46 : 250-256.
9BADENHORST D, M ASEKO M, TSOTETSI O J, et al. Cross-linking influences the impact of quantitative changes in myocardial collagen on cardiac stiffness and remodeling in hypertension in rats [J]. Cardiovasc Res, 2003, 57:632-641.
10BUTT R P, LAURENT G J, BISHOP J E. Collagen production and replication by cardiac fibroblasts is enhanced in response to diverse classes of growth factors[J]. EurJ Cell Biol, 1995, 68:330-335.