摘要
目的考察氨溴索雾化液中主要成分的配伍稳定性。方法按处方配制氨溴索雾化液，冰箱2～8℃冷藏保存，于0，1，2，3，4d观察雾化液外观，并采用反相高效液相色谱法测定盐酸氨溴索及地塞米松磷酸钠的含量。结果氨溴索雾化液在5d内外观无变化，主要成分含量均保持在初始浓度的96％以上。结论雾化液在2～8℃保存条件下，5d内性质稳定。
Objective To evaluate the compatible stability of main contents in the ambroxol nebulisation. Methods Ambroxol nebulisation was prepared according to the prescription and stored at 2 - 8 ℃. The appearance of the solution was observed at 0,1,2,3,4 d. Ambroxol Hydrochloride and dexamethasone sodium phosphate were determined by RP-HPLC. Results No obvious change was noted in appearance within 5 days. The main contents consistently remained over 96%. Conclusion Nebulisation could be stable at 2 -8 ℃ and used within 5 days.
出处
《医药导报》
CAS
2008年第11期1384-1385,共2页
Herald of Medicine
关键词
雾化液
稳定性
氨溴索
盐酸
地塞米松磷酸钠
Nebulisation
Stability
Ambroxol hydrochloride
Dexamethasone sodium phosphate
