磁共振波谱定量评估弥漫性轴索损伤的价值

The Role of MRS in Quantitatively Evaluate Diffuse Anonal Injury

磁共振波谱技术是一种无创性检测组织器官能量代谢、生化改变的分析技术,是活体神经化学物质代谢信息定量分析的方法,能在细胞代谢水平反映脑外伤后代谢的异常变化。脑弥漫性轴索损伤是颅脑损伤中重要的脑损伤类型,MRS可以检测出患者脑代谢物如N-乙酰天冬氨酸、胆碱、肌酸、谷氨酸等的变化,伤后几天至几周测定的代谢物水平与患者病情、预后密切相关。

Magnetic resonance spectroscopy（MRS） is a noninvasive technique which can detect the energy metabolism and chemical changes of the tissue. It offers a quantitative analysis method for measuring cerebral metabolites in vivo neurochemical information in tissues. This technique can be used to assess metabolic irregularities following brain injury on the level of cellular metabolism. Diffuse axonal injury（DAI） is one of the most common types of primary neuronal injury in patients with traumatic brain injury. MR spectroscopy can detect brain metabolites, such as N-acetylaspartate （ NAA）, totalcholine （ Cho）, totalcreatine（ Cre）, glutamine and glutamate（ Glx）, etc. Metabolite levels can be measured within days or weeks after injury, which has been demonstrated to be correlated with both initial severity and late clinical outcome.