丹参多酚酸盐对不稳定型心绞痛患者血小板功能的影响

Influence Study of Depside Salt from Saliva Miltiorrhiza on Blood Platelet Function in Unstable Angina Pectoris

目的研究丹参多酚酸盐对不稳定型心绞痛患者血小板功能的影响。方法将100例患者随机均分为治疗组(静脉滴注丹参多酚酸盐)和对照组,观察治疗前后血小板聚集率、P选择素变化情况。结果治疗组在降低血小板聚集率和P选择素方面优于对照组(P<0.05)。结论丹参多酚酸盐能明显抑制不稳定型心绞痛患者血小板的聚集和活化,改善微循环并防止微血栓形成。

Objective To study the influence of depside salt from sulvia mitiorrhiza on the bood platelet function in unstable angina pectoris. Methods 100 patients with unstable angina pectoris were randomly divided into two groups： the treatment group（50 cases） was given salvianolate by intravenous drip, and the control group（50 cases）. The blood platelet packing fraction and P-selectin were determined and the changes were compared before and after treatment. Results The blood platelet packing fraction and P-selectin was lower in the treatment group than in the control group（P〈0. 05）. Conclusion Depside salt from salvia miltiorrhiza can obviously inhibit aggregation and activation of platelet, improve the micro circulation, and prevent the micro- emboli formation in the patient with unstable angina pectoris.