食管鳞癌组织中葡萄糖转运蛋白-1表达的临床意义

Expression of Glucotransporter-1 in Different Development Stages of Esophageal Squamous Carcinoma

目的探讨葡萄糖转运蛋白-1(GLUT-1)的表达与食管鳞癌发生、发展的关系。方法对95例食管癌患者的手术切除标本及胃镜活检标本采用免疫组化S-P法检测GLUT-1表达水平。结果GLUT-1在食管鳞癌组织、癌旁不典型增生组织及正常食管组织中的阳性表达率、不同浸润程度时的表达率、临床病理分型的表达率、淋巴结转移的表达率之间差异有统计学意义(P<0.05)。结论GLUT-1在食管鳞癌的发生、发展中具有重要作用,有可能成为临床食管鳞癌诊断和判断预后的一个重要指标。

Objective To study the correlation of the expression of glucose transporter-1 （GLUT-1） and the different development stages of esophageal squamous carcinoma. Methods The samples were obtained from 95 patients with esophageal carcinoma. The esophageal tissue specimen was taken from operation or biopsy and the expression of GLUT-1 was detected by S- P immunohistochemical staining. The resuits were analyzed with chi- square test and exact probability. Results There was statistical significance in the differences of GLUT- 1 expression among normal esophageal tissue, atypical paracancerous hyperplasia, esophageal squamous carcinoma tissue, different infiltration degrees and pathologic types, and lymph nodes metastasis of esophageal squamous carcinoma （P 〈 0. 05）. Conclusion GLUT-1 plays an important role in the occurrence and progress of esophageal squamous carcinoma and may become a very important index for diagnosis, healing and prognosis assess of esophageal squamous carcinoma.