感冒口服液制备工艺研究

Study on Preparation Procedure of Ganmao Oral Liquid

目的确定感冒口服液的最佳制备工艺条件。方法通过考察提油时间及收油率,筛选出挥发油的最佳提取条件;以绿原酸的含量和浸膏得率为指标,采用正交试验法考察水提工艺条件;以绿原酸的含量为考核指标考察感冒口服液醇沉、水沉的最佳工艺条件。结果最佳工艺条件为煎煮2次,每次1h,加水量为10倍,醇沉浓度为60%,水沉时药液量∶加水量为1∶1。结论该试验结果可靠,筛选出的最佳工艺条件适合批量生产。

Objective To study the optimal preparation procedure of Ganmao Oral Liquid. Methods The best procedure for extracting volatile oil was screened according to the time of extraction and the rate of extraction. The procedure was studied by orthogonal design with the content of chlorogenic acid and the yield of extract as the detective markers. The best procedure for alcohol- precipitation concentration and water-precipitation concentration was studied with the content of chlorogenic acid as the detective markers. Results The best condition for preparation procedure was： boiling twice, 1 h each time, the amount of water used was 10 times, the alcohol-precipitation concentrations were 60% ,respectively. Conclusion The result is credible. It can be used for mass production.