喹硫平与氯丙嗪治疗女性精神分裂症的临床疗效比较

Clinical Effects Comparison of Quetiapine and Chlorpromazine Hydrochloride in Treatment of Female Schizophrenia

目的比较喹硫平与氯丙嗪治疗女性精神分裂症的疗效和安全性。方法选择患者60例,随机均分为两组,喹硫平组予喹硫平400～800mg/d,氯丙嗪组予氯丙嗪350～600mg/d,均2次/d口服,观察4周内的临床疗效和不良反应。结果总有效率喹硫平组为90.00%,氯丙嗪组为83.33%,两组比较,无显著性差异(P>0.05)。喹硫平组对兴奋躁动症状控制较好,与氯丙嗪组较高的锥体外系反应(20.00%)比较,差异有显著性(P<0.01),其他不良反应两组相仿,且程度较轻。结论喹硫平与氯丙嗪疗效相似,但喹硫平的不良反应轻,患者依从性好,适宜于女性患者应用。

Objective To compare the effectiveness and safety of quetiapine and chlorpromazine hydrochloride in the treatment of female schizophrenia. Methods The patients were randomly divided into two groups： quetiapine group （30 cases） were treated with oral quetiapine 400-800 rag/d, b. i. d,and the other group （30 cases） were treated with oral chlorpromazine hydrochloride 350-600 mg/d, b. i. d. The clinical effects and adverse reactions were assessed for 4 weeks by BPRS, TESS. Results The total effective rates of quetiapine group and chlorpromazine hydrochloride group were 90.00% and 83.33% respectively （P〉 0.05）, with no significant difference. The symptoms of exciting and mania were controlled better in quetiapine group. Compared with quetiapine group, chlorpromazine hydrochloride group had higher symptoms of extrapyramidal system （P〈 0. 01）. The other adverse reactions were mild and similar in two groups. Conclusion Quetiapine shows well tolerance and less adverse reactions especially suitable for the female and worthy to be recommended.