微小颗粒骨复合生物蛋白胶修复椎板缺损的有限元分析

Finite Element Analysis on Repairing Bone Defect with the Compound of Biocolloid and Autologous Micromorselized Bone

目的探讨自体微小颗粒骨复合生物蛋白胶修复椎板缺损的效果。研究生物蛋白胶作为微小颗粒骨载体,解决微小颗粒骨自身缺点的实际效果,为其临床应用提供依据。方法将9只犬的27节椎体随机分成4组并通过手术造成椎板骨缺损,以植入自体微小颗粒骨复合生物蛋白胶为实验组,同时设立单纯植入自体微小颗粒骨,单纯植入生物蛋白胶和不植入任何物质的空白对照组。术后8周,通过有限元方法对4组模型的应力和位移变化进行比较,并通过统计分析判断模型之间有无显著性差别。结果有限元方法证明自体微小颗粒骨复合生物蛋白胶组模型刚度最大,自体微小颗粒骨组模型次之,生物蛋白胶组模型刚度最小。结论自体微小颗粒骨复合生物蛋白胶可有效地修复椎板骨缺损;自体微小颗粒骨复合生物蛋白胶是良好的骨缺损修复材料。生物蛋白胶是微小颗粒骨的优良载体。

Objective To study the effects of combined use of autologous micromorselized bone and biocolloid on repair- ing bone defects. To probethe ability of the biocolloid as the cartier of the autogenous micromorselized bone, to solve the defects of micromorselized bone, and to provide the proof for the clinic. Methods 3he animal models of the lamina in lumbar defect were created by surgery in dogs, the experimental group was implanted the autogenous micromorselized bone whose carrier is biocolloid, while in the control groups, some was implanted the autogenous micromorselized bone, some was implanted the biocolloid, and others was implanted nothing. The defect - repairing capability for each of the 4 treatments was assessed by three - dimensional finite dement analysis at 8W. Results The effect of three - dimensional finite element analysis in the examination group was statistically significant different with the group implanted the autoge- nous micromorselized and the group implanted the biocolloid, the stability of the examination group is superior to either the group implanted the autogenous micromorselized or the group implanted the biocolloid. The stability of the group im- planted the autogenous micromorselized is superior to the group implanted the biocolloid. Conclusion Since both autol- ogous micromorselized bone with biocolloid and autologous micromorselized bone were effective in repairing lamina defects and they were obviously different in forming new bone, the former was an excellent bone repairing material as the latter. The biocolloid was the good cartier of the autogenous micromorselized bone. The autogenous micromorselized bone carried by biocolloid had more ability of repairing the bone defect than the group implanted the autogenous micromorselized bone or biocolloid.