多西紫杉醇联合5-氟尿嘧啶/亚叶酸钙双周方案治疗晚期胃癌的临床观察

Two Weekly Administration of Docetaxcel Combined with 5-Fu+LV for Advanced Gastric Cancer

目的观察多西紫杉醇联合5-氟尿嘧啶/亚叶酸钙双周方案治疗晚期胃癌的近期疗效、毒副反应及生活质量改善情况。方法30例晚期胃癌患者以多西紫杉醇75 mg/m2,d1静脉输注1 h;亚叶酸钙200mg/m2,d1静脉输注2 h;5-氟尿嘧啶400 mg/m2静脉输注0.5 h,然后以5-氟尿嘧啶2 400 mg/m2入泵48 h内泵入,每2周为1个疗程。所有病人至少接受4周期以上治疗。客观疗效（CR＋PR）及毒副反应按WHO进行评价,生活质量按临床受益反应（CBR）进行评价。结果30例均可评价疗效,完全缓解（CR）3例,部分缓解（PR）10例,总有效率43.3%,临床受益反应率63.3%,中位生存时间（MST）9.7个月,中位肿瘤进展时间（TTP）5.3个月。主要毒副反应为骨髓抑制、消化道反应,大部分为Ⅰ～Ⅱ级,可以耐受。结论多西紫杉醇联合5-氟尿嘧啶/亚叶酸钙双周方案治疗晚期胃癌的近期疗效好,毒副反应轻,耐受性好,病人生活质量明显改善。

Objective To observe the short - term curative effect, toxicity and quality of life with two weekly administration of docetaxel combined with 5 - Fu ＋ LV for advanced gastric cancer.Methods Thirty cases with advanced gastric cancer were observed. Docetaxcel 75 mg/m^2 iv for 1 h dl, LV 200 mg/m^2 iv for 2 h, 5 - Fu 400 mg/m^2 iv for half hour, and after that 2 400 mg/m^2 eiv for 48 h, and repeated every 14 days, To evaluate CR ＋ PR and toxicity refer to WHO standard, quality of life refer to CBR standard. Results All 30 cases were available for objective response, Total response rate was 43.3% clinical benefit effect rate was 66.7%. Median TTP was 5.3 months. The median survival time MST was 9.7 months. Myelosuppresion toxicity of digestive tract were Ⅰ - Ⅱ Grade and tolerable. Conclusion Patients trated with the two weekly administration of doeetaxel combined with 5 - Fu ＋ LV for advanced gastric cancer had a superior response rate, Quality of life is improved obviously.