早期足量足程复能剂治疗急性有机磷中毒60例

The Early Treatment for 60 Cases of AOPP with the Reactivation Agent of Full Dose and Enough Time of Therapy

目的:探讨早期足量足程复能剂治疗急性有机磷中毒(AOPP)的临床效果。方法:AOPP患者125例随机分成对照组(65例)和治疗组(60例),对照组以传统的阿托品治疗为主,辅以复能剂治疗;治疗组采用早期足量足程复能剂与小剂量阿托品治疗。观察两组死亡率、呼吸衰竭、阿托品不良反应及住院时间。结果:两组在死亡率、呼吸衰竭、阿托品不良反应、住院时间差异均有显著性(P<0.01)。结论:早期足量足程复能剂治疗急性有机磷中毒,能减少阿托品用量及不良反应,明显提高临床疗效及抢救成功率。

Objective： To investigate the clinical effect of the early treatment with the reactivation agent of full dose and enough time of therapy. Methods： 125 cases with AOPP were randomly divided into control group（n=65） and treatment group （n=60）, Patients in control group were treated mainly by traditional Atropine, along with the Reactivation Agent; Patients in treatment group were treated mainly by reactivation agent of full dose and enough time of therapy, with Atropine of small dose. Such items as death rate, respiratory failure, adverse effect of Atropine, length of stay in hospital were observed in the two groups. Results： Two groups have significant difference （P〈0.01） in death rate, respiratory failure, adverse effect of Atropine, length of stay in hospital. Conclusion： The early treatment for AOPP with the reactivation agent of full dose and enough Course can reduce dose of Atropine and adverse effect, greatly improve clinical effect and the salvage achievement ratio.