转录因子AP-2及其在肿瘤中作用机制

Transcription factor AP-2 and its effect on cancer

AP-2作为一个核转录因子家族，常以二聚体方式与特异的DNA序列结合，从而调节基因表达参与生长发育、细胞凋亡等重要生物学功能。病理状态下，AP-2能通过对细胞增殖和分化、细胞周期调控、细胞凋亡等各方面作用参与肿瘤的发生和发展。近年来，也有众多研究者寄希望以AP-2为靶点为临床治疗肿瘤提供新的思路。

AP-2,a nuclear transcription factor family,always binds to a typical DNA sequence in the dimer way,thus AP-2 can regulates the expression of many other genes and participate in the growth and development, apoptosis and many other physiological processes. Under pathological conditions, AP-2 also plays an important role in tumor genesis and development by influencing cell proliferation, differentiation, cell cycle regulation and apoptosis. Recent years,many researchers want to find new therapeutic strategies that target AP-2 in a series of human cancers.