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miRNA对肿瘤生物学特性的影响 被引量：2

Effect of miRNA on biological characteristics of tumor
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摘要 研究显示miRNA与肿瘤发生形成过程及其恶性生物学行为密切相关，作为一种调节分子可能参与了肿瘤的发生以及肿瘤细胞的增殖、分化、细胞凋亡、侵袭和转移及肿瘤耐药等的调节。miRNA靶标及其作用机制的深入研究可为解开肿瘤的发生发展机制及肿瘤治疗策略提供新的思路。 Studies indicate that miRNAs correlate closely with tumorigenesis and tumor biological behaviors, and play a significant role as a kind of regulating factor in tumorigenesis, tumor cells proliferation, differentiation, apoptosis, invasion and metastasis, as well as in drug resistance of tumors. Further study of the targets and mechanisms of miRNA may be helpful to recognize the characterization of tumor biology and etiology, and bring new strategies for tumor therapy.
作者 徐小方(综述) 刘斌(审校)
机构地区 第四军医大学口腔医院口腔生物学教研室
出处 《国际肿瘤学杂志》 CAS 2008年第10期747-750,共4页 Journal of International Oncology
关键词 微RNAS 肿瘤 基因表达调控 肿瘤形成过程 抗药性 肿瘤 MicroRNAs Neoplasms Gene expression regulation Neoplastic processes Drug resistance, neoplasm
分类号 R730.231 [医药卫生—肿瘤] R342.2 [医药卫生—基础医学]
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参考文献22

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  • 2Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA, 2004, 101 (9) : 2999-3004.
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同被引文献26

  • 1TRAN N, MCLEAN T, ZHANG X, et al. MicroRNAs expression profiles in head and neck cancer cell lines [ J ]. Biochem Biophys Res Commun, 2007, 358(1): 12-17.
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  • 7STSHLHUT E C E, FRANK J. The role of MicroRNAs in cancer [J]. Yale J Biol Med, 2006, 79(3) : 131 -140.
  • 8JANGA S C, VALLABHANENI S. MicroRNAs as post - transciptional machines and their interplay with cellular networks [ J ]. Adv Exp Med Biol, 2011, 722:59 -74.
  • 9TAKAKURA S, MITSUTAKE N, NAKASHIMA M, et al. Oncogenic role of miR - 17 - 92 cluster in an - aplastic thyroid cancer cells[J]. Cancer Sci, 2008, 99(6) : 1147 - 1154.
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国际肿瘤学杂志
2008年 第10期

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