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CDX2基因在肠型胃癌发展过程中的研究进展

CDX2 gene in development of intestinal type gastric cancer
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摘要 果蝇相关同源异型框转录因子2（CDX2）在肠上皮黏膜细胞的发育及保持形态、结构特征中起重要作用。肠型胃癌经历了正常胃黏膜、肠上皮化生到异型增生再到肠型胃癌的多步骤、多阶段逐渐发展的过程。迄今越来越多的研究发现，CDX2基因的异常表达与胃黏膜肠上皮化生和异型增生以及胃癌的发生密切相关。 CDX2 plays an important role in the development, maintaining shape, structural characteristics of intestinal epithelial cells. Intestinal type gastric cancer is thought to develop a multi-step and multi-phase process from normal gastric mucosa, intestinal metaplasia and dysplasia, ultimately to gastric cancer. So far, more and more studies have found that the abnormal expression of CDX2 gene plays an important role in development of intestinal metaplasia, dysplasia and intestinal carcinoma.
作者 蒋梦真(综述) 琚坚(审校)
机构地区 昆明医学院第二附属医院干疗消化科
出处 《国际肿瘤学杂志》 CAS 2008年第10期777-779,共3页 Journal of International Oncology
关键词 果蝇相关同源异型框转录因子2 肠上皮化生 胃肿瘤 Caudal- related homeobox transcription factor 2 Intestinal metaplasia Stomach neoplasms
分类号 R735.2 [医药卫生—肿瘤]
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参考文献22

  • 1Li MK, Folpe AL. CDX-2, a new marker for adenocarcinoma of gastrointestinal origin. Adv Anat Pathol, 2004,11 (2) : 101 - 105.
  • 2Silberg DG, Sullivan J, Kang E, et al. CDX2 ectopic expression induces gastric intestinal metaplasia in t ransgenic mice. Gastroenterology, 2002, 122(3):689-696.
  • 3Eda A,Osawa H,Yanaka I,et al. Expression of homeobox gene CDX2 precedes that of CDX1 during t he progression of intestinal metaplasia. J Gastroenterology, 2002, 37 (2) :94-100.
  • 4Mutoh H, Sakurai S, Satoh K, et al. Pericryptal fibroblast sheath in intestinal metaplasia and gastric carcinoma. Gut, 2005,54( 1 ) :33-39.
  • 5陈惠新,陈旻湖,宋鑫.尾型同源盒转录因子2在胃癌癌变多阶段组织中的表达及其意义[J].中华医学杂志,2006,86(4):247-249. 被引量：8
  • 6Satake S, Semba S, Matsuda Y, et al. Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma. Pathol Int, 2008, 58(3) : 156-163.
  • 7Matsuda Y, Semba S, Ueda J, et al. Gastric and intestinal claudin expression at the invasive front of gastric carcinoma. Cancer Sci ,2007, 98(7) : 1014-1019.
  • 8Tsukamoto T, Inada K,Tanaka H,et al. Down-regulation of a gastric trascription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdxl and Cdx2: Inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia. J Cancer Res Clin Oncol, 2004, 130(3) : 135-145.
  • 9Fan Z, Li J, Dong B, et al. Expression of Cdx2 and hepatocyte antigen in gastric carcinoma: Correlation with histologic type and implications for prognosis. Clin Cancer Res, 2005, 11 (17) : 6162-6170.
  • 10Woodland JG. CDX-2 and MIB-1 expression in the colorectum: correlation with morphological features of adenomatous lesions. Br J Biomed Sci, 2006, 63(2) : 68-73.

二级参考文献39

  • 1宋光耀,高志安,聂洪材,齐凤杰,席峥,李春宏,孔庆儒.HP感染与胃粘膜肠化中CDX2蛋白表达的关系[J].锦州医学院学报,2005,26(4):1-4. 被引量：2
  • 2Qualtrough D, Hinoi T, Fearon E, et al. Expression of CDX2 in normal and neoplastic human colon and during differentiation of an in vitro model system. Gut, 2002,51:184-190.
  • 3Mizoshita T, Tsukamoto T, Nakanishi H, et al. Expression of Cdx2 and phenotype of advanced gastric cancers: relationship with prognosis. J Cancer Res Clin Oncol, 2003,129:727-734.
  • 4Ebertr MP, Gunther T, Hoffmann J. Expression of metallothionein Ⅱ in intestinal metaplasia, dysplasia, and gastric cancer. Cancer Res, 2000, 156: 1995-2000.
  • 5Mallo GV, Rechreche H , Frigerio JM ,et al. Molecular cloning, sequencing and the expression of the mRNA encoding of Cdx1 and Cdx2. homeobox . Down regulation of Cdx1 and Cdx2 m RNA expression during colorectal carcinogenesis. Int J Cancer, 1997,74 :35-44.
  • 6Suh E, Traber P. An intestine-specific homeobox gene regulates proliferation and differention, Mol Cel Biol, 1996,16:619-623.
  • 7Silberg DG, Swain GP, Suh ER, et al. Cdx1 and Cdx2 expression during intestinal development. Gaslroenterology, 2000, 119 :961-971.
  • 8Chawengsaksophak K, James R, Hammond VE, et al. Homeosis and intestinal turnouts in Cdx2. mutant mice . Nature , 1997,386:84-87.
  • 9Ee HC, Bhathal ET ,Young PS, et al. Cdx2 homeodomain in protein expression in human and rat colorectal adenoma and carcinoma. Am J Pathol, 1995, 147: 586-592.
  • 10Eda A, Osawa H, Yanaka I, et al. Expression of homeobox gene Cdx2 precedes that of Cdx1 during the progression of intestinal metaplasia. J Gastroenterol, 2002,37:94-100.

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国际肿瘤学杂志
2008年 第10期

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