独特型蛋白致敏的树突细胞瘤苗治疗多发性骨髓瘤
ldiotype-pulsed dendritic cells in multiple myeioma immunotherapy
摘要
多发性骨髓瘤（MM）有独特型蛋白，为肿瘤特异性抗原。大量研究表明，使用负载独特型蛋白的树突细胞（DC）瘤苗进行主动免疫治疗，有助于消除（MM）微小残留病变，延长患者的无病生存期。近年来在抗肿瘤免疫治疗中的应用已成为肿瘤主动特异性免疫治疗的研究热点。
The idiotype of the monoclonal immunoglobulin expressed by multiple myeloma provides a tumor-specific antigen. Vaccination with idiotype-pulsed dendritic cells has expansive prospect to eliminate the minimal residual disease, prolong disease-free survival of multiple myeloma patients. It＇s application in antitumor immunotherapy has become the focus of active and specific immunotherapy of tumors.
出处
《国际肿瘤学杂志》
CAS
2008年第10期789-792,共4页
Journal of International Oncology
关键词
树突细胞
多发性骨髓瘤
独特型蛋白
Dendritic cells
Multiple myeloma
Immunoglobulin idiotypes
参考文献19
-
1Corthay A, Lundin KU, Munthe LA, et al. Immunotherapy in multiple rnyeloma: Id-specific strategies suggested by studies in animal models. Cancer Immunol Immunother, 2004, 53 (9) :759-769.
-
2Rossi M, Young JW. Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity. J Immunol, 2005, 175(3) :1373-1381.
-
3Curti A, Isidori A, Ferri E, et al. Generation of dendritic cells from positively selected CD14 + monocytes for anti-tumor immunotherapy. Leuk Lymphoma, 2004, 5 (7) : 1419-1428.
-
4Reichardt VL, Milazzo C, Bragger W, et al. Idiotype vaccination of multiple myeloma patients using monocyte-derived dendritic cells. Haematologica, 2003, 88 (10) : 1139-1149.
-
5Szmania S, Yi Q, Cottler-Fox M, et al. Clinical-grade myeloma Ag pre-loaded DC vaccines retain.potency after cryopreservation. Cytotherapy, 2005, 7(4):374-384.
-
6Han S, Wang B, Cotter M J, et al. Overcoming immune tolerance against muhiple myeloma with lentiviral calnexin-engineered dendritic cells. Mol Ther, 2008, 16(2) :269-279.
-
7Brinmes MK, Svane IM, Johnsen HE. Impaired functionality and phenotypic profile of dendritic cells from patients with multiple myeloma. Clin Exp Immunol, 2006, 144( 1 ) :76-84.
-
8Kovarova L, Buchler T, Pour L, et al. Dendritic cell counts and their subsets during treatment of multiple myeloma. Neoplasma,2007,54 (4) :297-303.
-
9Coscia M, Mariani S, Battaglio S, et al. Long- term follow- up of idio- type vaccination in human myeloma as a maintenance therapy after high-dose chemotherapy. Leukemia, 2004, 18 ( 1 ) : 139-145.
-
10Butch AW, Kelly KA, Munshi NC. Dendritic cells derived from muhiple myeloma patients efficiently internalize different classes of myeloma protein. Exp Hematol, 2001, 29( 1 ) :85-92.
-
1尹晓然,张梅,骆云雅,林秀,贺鹏程,陈丽梅,蔡瑞波,郭桂丽.骨髓瘤独特型抗原致敏树突细胞诱导的主动免疫反应[J].癌症,2005,24(6):657-662. 被引量：2
-
2刘宝瑞,吴敏慧,刘文超.树突细胞瘤苗的研究现状及前景[J].陕西肿瘤医学,2000,8(1):56-58.
-
3林秀.多发性骨髓瘤主动免疫治疗的研究进展[J].国外医学（输血及血液学分册）,2003,26(2):142-145.
-
4刘宝瑞,薛妍.转移性肾细胞癌的治疗进展[J].肿瘤研究与临床,2002,14(5):355-356.
-
5马玉强,张明辉.负载肝癌抗原树突细胞瘤苗对癌细胞免疫抑制作用[J].中国老年学杂志,2010,30(16):2322-2324. 被引量：1
-
6吴刚,顾红光,韩本立,裴雪涛.γ射线诱导癌细胞凋亡致敏树突状细胞后的免疫应答[J].中华放射医学与防护杂志,2002,22(1):13-16. 被引量：1
-
7钱振超.肿瘤主动特异性免疫治疗的进展[J].中国肿瘤生物治疗杂志,1997,4(3):171-173. 被引量：4
-
8周娟,徐立春.肿瘤疫苗的研究现况及进展[J].医学综述,2006,12(22):1364-1366. 被引量：2
-
9李青,邵斯亮,李博,赵庆利,魏学斌,李顺.前列腺癌树突细胞瘤苗的制备及其应用[J].山东医药,2007,47(8):4-6.
-
10马玉强,李志梁,张明辉,胡万宁.负载肝癌抗原树突细胞瘤苗抑制胶原合成免疫作用[J].中国老年学杂志,2011,31(4):630-631.
